Neuronal Sianallina of Information Imoortant to Visual Recognition‐Memory in Rat Rhinal aid Neighbouring Cortices
Neuronal Sianallina of Information Imoortant to Visual Recognition‐Memory in Rat Rhinal aid Neighbouring Cortices
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大鼠鼻腔辅助邻近皮层信息不朽的神经元 Sianallina 视觉识别记忆
DOI：
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发表时间：
1995
影响因子：
3.4
通讯作者：
J. Aggleton
中科院分区：
文献类型：
--
作者：
X. O. Zhu;Malcolm W. Brown;J. Aggleton
进行这项研究是为了发现大鼠皮层是否含有神经元，这些神经元发出有关先前刺激发生的信号，就像在灵长类动物中发现的那样。记录了396个单个神经元的活动，同时向未麻醉的大鼠展示物体。刺激重复和刺激的相对熟悉性对神经元反应的影响。采样区域为鼻（内嗅和嗅周）皮质、颞叶皮质TE区、外侧枕叶皮质和海马结构。在185个反应神经元中，有63个（34%）对物体的第一次呈现的反应与第二次呈现的反应有显著差异;其中39个神经元在重复刺激时的反应较小，而24个神经元的反应较大。非海马皮质的递减反应发生率高于海马结构，而海马结构的递增反应发生率高于其他皮质区域。67个神经元中有15个（22%）对不熟悉的物体的反应与对非常熟悉的物体的反应有显著差异; 12个神经元的反应在重复刺激时较小，3个神经元的反应较大;这些神经元中的大多数位于TE区。10个熟悉性神经元的反应随刺激的相对熟悉性而显著变化，但不随刺激的重复而显著变化; 7个近感神经元的反应随刺激的重复而显著变化，但不随刺激的相对熟悉性而显著变化。因此，有关刺激重复和熟悉性的信息在大鼠皮层的单个神经元水平上被单独编码。结果表明，在大鼠皮层中，在猴皮层中有神经元，信号的信息有关的先前发生的刺激，这些信息是重要的识别记忆，工作记忆和启动记忆。
This study was conducted to discover whether the rat cortex contains neurons that signal information concerning the previous occurrence of stimuli, as has been found in the primate. Recordings of the activity of 396 single neurons were made while unanaesthetized rats were shown objects. The effects on neuronal responsiveness of stimulus repetition and of the relative familiarity of the stimuli were sought. The areas sampled were the rhinal (entorhinal and perirhinal) cortex, area TE of the temporal cortex, the lateral occipital cortex and the hippocampal formation. The response to the first presentations of objects was significantly different from that to their second presentations for 63 (34%) of the 185 responsive neurons; for 39 of the neurons the response was smaller when the stimulus was repeated, whereas for 24 it was larger. The incidence of decremental responses was higher in the non‐hippocampal cortex than in the hippocampal formation, while the incidence of incremental responses was higher in the hippocampal formation than other cortical areas. The response to unfamiliar objects was significantly different from that to highly familiar objects for 15 (22%) of 67 responsive neurons so tested; for 12 of the neurons the response was smaller when the stimulus was repeated, and for three it was larger; most of these neurons were found in area TE. The responses of ten familiarity neurons varied significantly with the relative familiarity of the stimuli but not with stimulus repetition; the responses of seven recency neurons varied significantly upon stimulus repetition but not with the relative familiarity of the stimuli. Thus information concerning stimulus repetition and familiarity is separably encoded at the single neuron level in the rat cortex. The results demonstrate that in the rat cortex as in the monkey cortex there are neurons that signal information concerning the prior occurrence of stimuli; such information is of importance to recognition memory, working memory and priming memory.
影响因子：
1.9
作者：
T. Otto;H. Eichenbaum
通讯作者：
T. Otto;H. Eichenbaum