The transferrin receptor and the targeted delivery of therapeutic agents against cancer.
The transferrin receptor and the targeted delivery of therapeutic agents against cancer.
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DOI：
10.1016/j.bbagen.2011.07.016
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发表时间：
2012-03
影响因子：
3
通讯作者：
Penichet, Manuel L.
中科院分区：
文献类型：
--
作者：
Daniels, Tracy R.;Bernabeu, Ezequiel;Rodriguez, Jose A.;Patel, Shabnum;Kozman, Maggie;Chiappetta, Diego A.;Holler, Eggehard;Ljubimova, Julia Y.;Helguera, Gustavo;Penichet, Manuel L.
传统的癌症治疗可以成功地摧毁肿瘤，但也可能导致危险的副作用。因此，许多靶向治疗正在开发中。转铁蛋白受体（TfR）通过与转铁蛋白相互作用在细胞铁摄取中起作用。这种受体是癌症靶向治疗的有吸引力的分子，因为它在许多癌症类型的表面上被上调并被有效地内化。这种受体可以通过两种方式靶向：1）用于将治疗分子递送到恶性细胞中或2）阻断受体的天然功能，直接导致癌细胞死亡。在这篇文章中，我们讨论了用于靶向TfR以将治疗剂递送到癌细胞中的策略。我们提供了一个总结的抗癌药物的种类繁多，已被交付到癌细胞采用各种受体结合分子，包括Tf，抗TfR抗体，或TfR结合肽单独或与载体分子，包括纳米粒子和病毒的组合。靶向TfR已被证明在递送许多不同的治疗剂和在体外和体内在癌细胞中引起细胞毒性作用方面是有效的。TfR在靶向治疗中的广泛应用证明了靶向这种受体用于治疗恶性细胞的多功能性。预计该领域的更多进展将进一步提高靶向TfR用于癌症治疗的治疗潜力，导致靶向该受体的分子的临床试验数量增加。
Traditional cancer therapy can be successful in destroying tumors, but can also cause dangerous side effects. Therefore, many targeted therapies are in development. The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin. This receptor is an attractive molecule for the targeted therapy of cancer since it is upregulated on the surface of many cancer types and is efficiently internalized. This receptor can be targeted in two ways: 1) for the delivery of therapeutic molecules into malignant cells or 2) to block the natural function of the receptor leading directly to cancer cell death. In the present article we discuss the strategies used to target the TfR for the delivery of therapeutic agents into cancer cells. We provide a summary of the vast types of anti-cancer drugs that have been delivered into cancer cells employing a variety of receptor binding molecules including Tf, anti-TfR antibodies, or TfR-binding peptides alone or in combination with carrier molecules including nanoparticles and viruses. Targeting the TfR has been shown to be effective in delivering many different therapeutic agents and causing cytotoxic effects in cancer cells in vitro and in vivo. The extensive use of TfR for targeted therapy attests to the versatility of targeting this receptor for therapeutic purposes against malignant cells. More advances in this area are expected to further improve the therapeutic potential of targeting the TfR for cancer therapy leading to an increase in the number of clinical trials of molecules targeting this receptor.
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影响因子：
5.6
作者：
Cimini, A.;Mei, S.;Ippoliti, R.
通讯作者：
Ippoliti, R.
DOI：
10.3181/0808-mr-250
发表时间：
2009-02
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Blanco E;Kessinger CW;Sumer BD;Gao J
通讯作者：
Gao J
影响因子：
64.5
作者：
Cheng, Y;Zak, O;Walz, T
通讯作者：
Walz, T
影响因子：
5.8
作者：
Bhadra, D;Bhadra, S;Jain, NK
通讯作者：
Jain, NK
DOI：
10.1111/j.1600-0897.1991.tb01078.x
发表时间：
1991-04-01
影响因子：
3.6
作者：
BARABAS, K;SIZENSKY, JA;FAULK, WP
通讯作者：
FAULK, WP