Diffusion tensor imaging in cubital tunnel syndrome.
Diffusion tensor imaging in cubital tunnel syndrome.
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DOI：
10.1038/s41598-021-94211-7
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发表时间：
2021-07-22
影响因子：
4.6
通讯作者：
Wade RG
中科院分区：
文献类型：
--
作者：
Griffiths TT;Flather R;Teh I;Haroon HA;Shelley D;Plein S;Bourke G;Wade RG
肘管综合征（CuTS）是第二常见的压迫性神经病变。为了提高诊断和手术患者的选择，迫切需要开发一种可靠和客观的尺神经“健康”测试。扩散张量成像（DTI）表征组织微观结构，可以识别正常尺骨与受切口影响的尺骨的差异。本研究的目的是比较健康（无症状）成人和等待手术的切口患者尺神经的DTI指标。3.0 T时，采用30个扩散敏化梯度方向，b值为800 s/mm2, 4个信号平均值的单次回波平面成像（55个轴向切片，3mm厚，1.5 mm2面内）获得DTI。重复序列，反转相位编码方向。使用FMRIB软件库（FSL）对数据进行组合和校正，并使用DSI Studio中的广义q采样成像对数据进行重建。提取尺神经长度的分数各向异性（FA）、定量各向异性（QA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD），并用混合效应线性回归进行比较。13名健康对照者（8名男性，5名女性）和8名CuTS患者（6名男性，2名女性）完成研究。在尺神经的整个长度上，切口患者的扩散更加各向同性。总的来说，cut患者的FA比对照组低6%，最大的差异是在肘管近端（平均差0.087 [95% CI 0.035, 0.141]）。CuTS患者的RD也高于对照组，在前臂中观察到的差异最大（平均差异为0.252 × 10-4 mm2/s [95% CI 0.085 × 10 - 4,0.419 × 10-4]）。患者与对照组在QA、MD或AD方面无显著差异。在整个尺神经长度上，cut患者的分数各向异性和径向弥漫性与健康对照组不同。这些发现表明，DTI可以提供尺神经的客观评估，并可能改善切口的管理。
Cubital tunnel syndrome (CuTS) is the 2nd most common compressive neuropathy. To improve both diagnosis and the selection of patients for surgery, there is a pressing need to develop a reliable and objective test of ulnar nerve ‘health’. Diffusion tensor imaging (DTI) characterises tissue microstructure and may identify differences in the normal ulnar from those affected by CuTS. The aim of this study was to compare the DTI metrics from the ulnar nerves of healthy (asymptomatic) adults and patients with CuTS awaiting surgery. DTI was acquired at 3.0 T using single-shot echo-planar imaging (55 axial slices, 3 mm thick, 1.5 mm2 in-plane) with 30 diffusion sensitising gradient directions, a b-value of 800 s/mm2 and 4 signal averages. The sequence was repeated with the phase-encoding direction reversed. Data were combined and corrected using the FMRIB Software Library (FSL) and reconstructed using generalized q-sampling imaging in DSI Studio. Throughout the length of the ulnar nerve, the fractional anisotropy (FA), quantitative anisotropy (QA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were extracted, then compared using mixed-effects linear regression. Thirteen healthy controls (8 males, 5 females) and 8 patients with CuTS (6 males, 2 females) completed the study. Throughout the length of the ulnar nerve, diffusion was more isotropic in patients with CuTS. Overall, patients with CuTS had a 6% lower FA than controls, with the largest difference observed proximal to the cubital tunnel (mean difference 0.087 [95% CI 0.035, 0.141]). Patients with CuTS also had a higher RD than controls, with the largest disparity observed within the forearm (mean difference 0.252 × 10–4 mm2/s [95% CI 0.085 × 10–4, 0.419 × 10–4]). There were no significant differences between patients and controls in QA, MD or AD. Throughout the length of the ulnar nerve, the fractional anisotropy and radial diffusivity in patients with CuTS are different to healthy controls. These findings suggest that DTI may provide an objective assessment of the ulnar nerve and potentially, improve the management of CuTS.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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