Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study.
Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study.
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DOI：
10.1001/2013.jamaneurol.340
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发表时间：
2013-03-01
期刊：
影响因子：
29
通讯作者：
Cullum, C. Munro
中科院分区：
文献类型：
--
作者：
Hart, John, Jr.;Kraut, Michael A.;Womack, Kyle B.;Strain, Jeremy;Didehbani, Nyaz;Bartz, Elizabeth;Conover, Heather;Mansinghani, Sethesh;Lu, Hanzhang;Cullum, C. Munro
评估老年前NFL球员的认知障碍和抑郁症的存在，并确定这些功能障碍的神经影像学相关性。比较有认知障碍和抑郁症的老年NFL球员与没有这些功能障碍的球员，以及美国北德克萨斯州研究中心的健康对照。我们进行了一项横断面研究的退休职业足球运动员有和没有历史的脑震荡招募从北德克萨斯州地区，沿着与年龄，教育和智商匹配的控制。我们研究了34名退役的NFL球员（平均年龄62岁）的神经和神经心理学。一个26人的子集也进行了详细的神经影像学检查，在这个子集中的成像数据进行了比较，在26个健康匹配的对照获得的成像数据。神经心理学测量、抑郁症的临床诊断、白色物质病理学的神经影像学测量和脑血流量（CBF）的测量。在34名参与者中，20名认知正常，4名被诊断为固定认知缺陷，8名轻度认知障碍，2名痴呆; 8名被诊断为抑郁症。在获得神经影像学数据的亚组中，认知受损（CI）参与者在命名、单词发现和视觉/言语情景记忆测试中表现出最大的缺陷。我们发现CI球员和抑郁球员的白色物质异常与他们各自的控制相比有显着差异。脑梗死组的局部血流差异（左颞极、顶下小叶、上级颞回）与神经认知功能受损（记忆、命名和单词发现问题）相关。与对照组相比，认知缺陷和抑郁症似乎在老年NFL球员中更常见。这些缺陷与白色物质异常和区域CBF变化相关。
To assess for the presence of cognitive impairment and depression in aging former NFL players, and identify neuroimaging correlates of these dysfunctions. Comparison of aging NFL players with cognitive impairment and depression to those without these dysfunctions and with matched healthy controls Research center in the North Texas region of the United States. We performed a cross-sectional study of retired professional football players with and without a history of concussion recruited from the North Texas region, along with age-, education-, and IQ-matched controls. We studied thirty-four retired NFL players (mean age 62) neurologically and neuropsychologically. A subset of 26 also underwent detailed neuroimaging; imaging data in this subset were compared to imaging data acquired in 26 healthy matched controls. Neuropsychological measures, clinical diagnoses of depression, neuroimaging measures of white matter pathology, and a measure of cerebral blood flow (CBF). Of the 34 participants, 20 were cognitively normal, 4 were diagnosed with a fixed cognitive deficit, 8 with Mild Cognitive Impairment, and 2 with dementia; 8 were diagnosed with depression. Of the subgroup in which neuroimaging data were acquired, cognitively impaired (CI) participants showed greatest deficits on tests of naming, word finding, and visual/verbal episodic memory. We found significant differences in white matter abnormalities in CI players and depressed players compared to their respective controls. Regional blood flow differences in the CI group (left temporal pole, inferior parietal lobule, superior temporal gyrus) corresponded to regions associated with impaired neurocognitive performance (problems with memory, naming and word finding). Cognitive deficits and depression appear to be more common in aging NFL players compared to controls. These deficits are correlated with white matter abnormalities and changes in regional CBF.
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