Cobalt injections into the pedunculopontine nuclei attenuate the reflex diaphragmatic responses to muscle contraction in rats.
Cobalt injections into the pedunculopontine nuclei attenuate the reflex diaphragmatic responses to muscle contraction in rats.
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将钴注射到桥脚核中会减弱大鼠膈肌对肌肉收缩的反射反应。
DOI：
10.1152/japplphysiol.00652.2003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Waldrop,TonyG
中科院分区：
文献类型：
--
作者：
Plowey,EdwardD;Waldrop,TonyG
以往的研究表明，脚桥核（PPN）的神经元在静态肌肉收缩过程中被激活。此外，通过电刺激或化学去抑制激活PPN与通过呼吸肌肌电图记录观察到的呼吸活动增加相关。本实验探讨了PPN参与调节氯醛糖-氨基甲酸乙酯麻醉大鼠肌肉收缩反射性运动反应的可能性。膈肌反应单侧静态后肢肌肉收缩，诱发通过电刺激胫神经，记录之前和之后的双边微量注射的突触阻滞剂（氯化钴）到PPN。PPN内微量注射CoCl 2后，呼吸频率（9.0 ± 1.0次/min）和肌电活动（14.6 ± 3.3单位/min）的峰值反射增加（分别为2.6 ± 0.9次/min和4.6 ± 2.1单位/min）减弱。在去压力神经支配的动物亚组中观察到一致的神经反应。对照实验表明，PPN突触阻滞对肌肉收缩的心血管反应没有影响。结果进行了讨论的PPN在调制的反射呼吸的调整，伴随着肌肉活动的潜在作用。
Previous studies have suggested that neurons in the pedunculopontine nucleus (PPN) are activated during static muscle contraction. Furthermore, activation of the PPN, via electrical stimulation or chemical disinhibition, is associated with increases in respiratory activity observed via diaphragmatic electromyogram recordings. The present experiments address the potential for PPN involvement in the regulation of the reflex diaphragmatic responses to muscle contraction in chloralose-urethane anesthetized rats. Diaphragmatic responses to unilateral static hindlimb muscle contraction, evoked via electrical stimulation of the tibial nerve, were recorded before and subsequent to bilateral microinjections of a synaptic blockade agent (CoCl2) into the PPN. The peak reflex increases in respiratory frequency (9.0 ± 1.0 breaths/min) and minute integrated diaphragmatic electromyogram activity (14.6 ± 3.3 units/min) were attenuated after microinjection of CoCl2into the PPN (2.6 ± 0.9 breaths/min and 4.6 ± 2.1 units/min, respectively). Consistent diaphragmatic responses were observed in the subset of animals that were barodenervated. Control experiments suggest no effects of PPN synaptic blockade on the cardiovascular responses to muscle contraction. The results are discussed in terms of a potential role for the PPN in modulation of the reflex respiratory adjustments that accompany muscular activity.
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DOI：
10.1016/0002-9149(85)91053-7
发表时间：
1985
期刊：
The American journal of cardiology
影响因子：
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作者：
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Mitchell,JH
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影响因子：
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作者：
PC Nolan;TG Waldrop
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作者：
I. Solomon;T. Adamson
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T. Adamson
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2.5
作者：
VINCENT, SR;SATOH, K;FIBIGER, HC
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FIBIGER, HC
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DOI：
10.1152/ajpregu.2001.281.4.r1127
发表时间：
2001
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Hayashi,N;Hayes,SG;Kaufman,MP
通讯作者：
Kaufman,MP