Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
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DOI：
10.1155/2010/170153
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发表时间：
2010
影响因子：
4.6
通讯作者：
Rich SS
中科院分区：
文献类型：
--
作者：
Burdon KP;Rudock ME;Lehtinen AB;Langefeld CD;Bowden DW;Register TC;Liu Y;Freedman BI;Carr JJ;Hedrick CC;Rich SS
目标。5-脂氧合酶途径的基因是动脉粥样硬化的有力候选者。我们假设ALOX 12、ALOX 15、ALOX 5和ALOX 5AP基因多态性与多血管床亚临床动脉粥样硬化相关。方法.有两个或两个以上兄弟姐妹患有2型糖尿病的家庭和他们的非糖尿病兄弟姐妹作为糖尿病心脏研究（DHS）的一部分进行了研究。对828名欧洲裔美国糖尿病患者和170名非糖尿病患者的同胞进行ALOX 12、ALOX 15、ALOX 5和ALOX 5AP基因的SNP分型。获得动脉粥样硬化（IMT、冠状动脉（CorCP）、颈动脉（CarCP）和主动脉（AorCP）钙化斑块）的亚临床指标。结果观察到ALOX 12与CorCP、ALOX 5与CorCP、AorCP和IMT以及ALOX 5AP与CorCP和CarCP之间的相关性，与已知的流行病学风险因素无关。此外，与动脉粥样硬化相关的脂氧合酶途径SNP与炎症标志物（CRP，ICAM-1）和钙化（MGP）相关。 结论. ALOX 12、ALOX 5和ALOX 5AP内的多态性与亚临床动脉粥样硬化和2型糖尿病家族疾病的生物标志物遗传相关。这些结果表明，脂氧合酶途径基因的变异可能对决定心血管疾病风险的多种成分具有多效性作用。
Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. Methods. Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS). European American diabetic (n = 828) and nondiabetic (n = 170) siblings were genotyped for SNPs in the ALOX12, ALOX15, ALOX5, and ALOX5AP genes. Subclinical measures of atherosclerosis (IMT, coronary (CorCP), carotid (CarCP) and aortic (AorCP) calcified plaque) were obtained. Results. Associations were observed between ALOX12 with CorCP, ALOX5 with CorCP, AorCP, and IMT, and ALOX5AP with CorCP and CarCP, independent of known epidemiologic risk factors. Further, lipoxygenase pathway SNPs that were associated with measures of atherosclerosis were associated with markers of inflammation (CRP, ICAM-1) and calcification (MGP). Conclusions. Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes. These results suggest that variants in lipoxygenase pathway genes may have pleiotropic effects on multiple components that determine risk of cardiovascular disease.
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影响因子：
30.8
作者：
Helgadottir, A;Manolescu, A;Stefansson, K
通讯作者：
Stefansson, K
影响因子：
30.8
作者：
Helgadottir, A;Manolescu, A;Stefansson, K
通讯作者：
Stefansson, K
影响因子：
2.1
作者：
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通讯作者：
Dudbridge, F
DOI：
10.1161/01.atv.0000245793.83158.06
发表时间：
2006-12-01
影响因子：
8.7
作者：
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通讯作者：
Booth, Sarah L.
影响因子：
20.1
作者：
Mehrabian, M;Allayee, H;Lusis, AJ
通讯作者：
Lusis, AJ