Hyperinsulinemia is a determinant of membrane fluidity of erythrocytes in essential hypertension.
Hyperinsulinemia is a determinant of membrane fluidity of erythrocytes in essential hypertension.
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高胰岛素血症是原发性高血压中红细胞膜流动性的决定因素。
DOI：
10.1016/s0895-7061(00)01247-4
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发表时间：
2001
影响因子：
3.2
通讯作者：
Y. Masuyama
中科院分区：
文献类型：
--
作者：
K. Tsuda;Y. Kinoshita;I. Nishio;Y. Masuyama
在本研究中，为了确定胰岛素在调节膜功能中的可能作用，我们研究了原发性高血压患者和血压正常者血浆胰岛素水平与红细胞膜流动性之间的关系。用电子顺磁共振和自旋标记法测定了高血压和正常血压受试者红细胞的膜流动性。从红细胞膜的电子顺磁共振谱中获得的序参量（S为5-硝基氧硬脂酸酯）和峰高比（ho/h-1为16-硝基氧硬脂酸酯）在原发性高血压患者中明显高于血压正常者。结果表明，原发性高血压患者红细胞膜流动性低于正常血压者。高血压患者空腹血浆胰岛素浓度也显著高于血压正常者。此外，血浆胰岛素水平与序参量（S）和峰高比（ho/h-1）呈显著相关，表明血浆胰岛素水平越高，红细胞膜流动性越低。这些结果支持了胰岛素可能积极参与高血压病红细胞膜流动性调节的假说。Am J Hypertens 2001;14：419-423 © 2001 American Journal of Hypertension，Ltd.
In the present study, to determine a possible role of insulin in the regulation of membrane functions, we have examined the relationship between plasma insulin level and membrane fluidity of erythrocytes in patients with essential hypertension and normotensive subjects. Membrane fluidity of erythrocytes obtained from hypertensive and normotensive subjects were evaluated by means of an electron paramagnetic resonance and spin-labeling method. The order parameter (S for 5-nitroxide stearate) and the peak height ratio (ho/h-1 for 16-nitroxide stearate) obtained from electron paramagnetic resonance spectra of erythrocyte membranes were significantly higher in patients with essential hypertension than in normotensive subjects. The finding indicated that the erythrocyte membrane fluidity was lower in essential hypertension than in normotensive controls. The plasma concentration of insulin while fasting was also significantly greater in hypertensive patients than in normotensive subjects. In addition, the plasma insulin level was significantly correlated with the values of the order parameter (S) and the peak height ratio (ho/h-1), which showed that the higher plasma insulin was associated with the lower membrane fluidity of erythrocytes. These results support the hypothesis that insulin may actively participate in the regulation of membrane fluidity of erythrocytes in essential hypertension. Am J Hypertens 2001;14:419–423 © 2001 American Journal of Hypertension, Ltd.
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DOI：
10.1016/s0006-291x(86)80321-7
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影响因子：
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DOI：
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DOI：
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发表时间：
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影响因子：
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DOI：
10.1210/jcem.76.3.8445010
发表时间：
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期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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