The genetic basis of interspecies host preference differences in the model parasitoid Nasonia.
The genetic basis of interspecies host preference differences in the model parasitoid Nasonia.
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DOI：
10.1038/hdy.2009.145
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发表时间：
2010-03
期刊：
影响因子：
3.8
通讯作者：
Werren, J. H.
中科院分区：
文献类型：
--
作者：
Desjardins, C. A.;Perfectti, F.;Bartos, J. D.;Enders, L. S.;Werren, J. H.
寄主偏好的遗传基础仅在少数物种中进行了研究。它与进化生物学中的重要问题有关，包括同域物种形成，通才适应与专才适应，以及寄生虫-宿主共同进化。在这里，我们显示了一个主要的位点强烈影响寄主偏好在纳索尼亚。纳索尼亚是一种利用蝇蛹的寄生蜂；vitripennis是一种多面手，它寄生于多种宿主，而N. giraulti则专门寄生于原蝴蝶（鸟蛉）。在以原蝇和石腹蝇为对象的实验室选择实验中，玻璃翅螨对石腹蝇表现出偏好，而giraulti则对原蝇表现出偏好。通过一系列的种间杂交，我们已经将一个主要的影响寄主偏好的基因座从giraulti渗入到玻璃翅螨中。giraulti等位基因是显性的，相对于隐性的玻璃翅扁豆等位基因，它在渗入系中大大增加了对原萼扁豆蛹的偏好。通过利用纳索尼亚基因分型芯片，我们确定了4号染色体上的渗入区域为16兆碱基，尽管需要更完整的分析来确定该属宿主偏好的确切遗传结构。据我们所知，这是第一次将寄主偏好从一种寄生物种渗入到另一种寄生物种，也是物种间行为基因渗入的少数案例之一。
The genetic basis of host preference has been investigated in only a few species. It is relevant to important questions in evolutionary biology, including sympatric speciation, generalist versus specialist adaptation, and parasite-host co-evolution. Here we show that a major locus strongly influences host preference in Nasonia. Nasonia are parasitic wasps that utilize fly pupae; N. vitripennis is a generalist that parasitizes a diverse set of hosts whereas N. giraulti specializes on Protocalliphora (bird blowflies). In laboratory choice experiments using Protocalliphora and Sarcophaga (flesh flies), N. vitripennis shows a preference for Sarcophaga while N. giraulti shows a preference for Protocalliphora. Through a series of interspecies crosses we have introgressed a major locus affecting host preference from N. giraulti into N. vitripennis. The N. giraulti allele is dominant and greatly increases preference for Protocalliphora pupae in the introgression line relative to the recessive N. vitripennis allele. Through the utilization of a Nasonia genotyping microarray, we have identified the introgressed region as 16 megabases of chromosome 4, although a more complete analysis is necessary to determine the exact genetic architecture of host preference in the genus. To our knowledge, this is the first introgression of the host preference of one parasitoid species into another, as well as one of the few cases of introgression of a behavioral gene between species.
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