Ex vivo diffusion tensor MRI reflects microscopic structural remodeling associated with aging and disease progression in normal and cardiomyopathic Syrian hamsters.
Ex vivo diffusion tensor MRI reflects microscopic structural remodeling associated with aging and disease progression in normal and cardiomyopathic Syrian hamsters.
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DOI：
10.1002/nbm.1394
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发表时间：
2009-10
影响因子：
2.9
通讯作者：
Yu, Xin
中科院分区：
文献类型：
--
作者：
Li, Wen;Lu, Ming;Banerjee, Suhanti;Zhong, Jia;Ye, Allen;Molter, Joseph;Yu, Xin
扩张型心肌病（DCM）是心脏病患者死亡和发病的主要原因。衰老往往是一个被忽视的病理条件的病因。量化DCM和衰老相关的心脏结构重构对指导和评估治疗干预措施具有重要意义。扩散张量磁共振成像（DTMRI）最近被用于三维肌纤维结构的无损表征。在这项研究中，我们探讨了DTMRI在描绘衰老和DCM心脏微观结构重塑方面的潜力。研究对象为6月龄（n = 10）和9月龄（n = 11） DCM （TO-2）仓鼠及其同龄对照（F1β）。衰老和DCM心脏均表现出扩散系数增加和扩散各向异性降低。DCM心脏的DTMRI图像也显示了一个以径向扩散率降低和FA增加为特征的成像像素亚群。这些像素点的位置与x线CT成像确定的钙沉积区域定性一致。组织学分析证实衰老和DCM心脏细胞外空间扩大，DCM心脏有大量钙沉积。这些结果表明，DTMRI可以在不使用外源性造影剂的情况下，在组织和细胞水平上提供一种无创技术来描绘与衰老和DCM进展相关的结构重塑。
Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in cardiac patients. Aging is often an ignored etiology of pathological conditions. Quantification of DCM and aging associated cardiac structural remodeling is important in guiding and evaluating therapeutic interventions. Diffusion tensor magnetic resonance imaging (DTMRI) has recently been used for nondestructive characterization of three-dimensional myofiber structure. In this study, we explored the potential of DTMRI in delineating microscopic structural remodeling in aging and DCM hearts. Six month (n = 10) and nine month old (n = 11) DCM (TO-2) hamsters and their age-matched controls (F1β) were characterized. Both aging and DCM hearts showed increased diffusivity and decreased diffusion anisotropy. DTMRI images of DCM hearts also revealed a subgroup of imaging pixels characterized by decreased radial diffusivity and increased FA. The location of these pixels showed qualitative agreement with regions of calcium deposition determined by X-ray CT imaging. Histological analysis confirmed expanded extracellular space in aging and DCM hearts as well as substantial calcium deposition in DCM hearts. These results suggest that DTMRI may provide a noninvasive technique to delineate structural remodeling associated with aging and DCM progression at the tissue and cellular level without the use of an exogenous contrast agent.
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影响因子：
20.1
作者：
GARRIDO, L;WEDEEN, VJ;KANTOR, HL
通讯作者：
KANTOR, HL
DOI：
10.1152/ajpheart.1998.275.6.h2308
发表时间：
1998-12-01
影响因子：
4.8
作者：
Scollan, DF;Holmes, A;Forder, J
通讯作者：
Forder, J
影响因子：
6.4
作者：
Hsu, EW;Henriquez, CS
通讯作者：
Henriquez, CS
影响因子：
20.1
作者：
Chimenti, C;Kajstura, J;Anversa, P
通讯作者：
Anversa, P
影响因子：
6.4
作者：
Petrie, CJ;Mark, PB;Dargie, HJ
通讯作者：
Dargie, HJ