Calorie restriction in rodents: Caveats to consider.
Calorie restriction in rodents: Caveats to consider.
复制标题
啮齿动物的卡路里限制：要考虑的警告。
DOI：
10.1016/j.arr.2017.05.008
复制
发表时间：
2017-10
影响因子：
13.1
通讯作者：
de Cabo R
中科院分区：
文献类型：
--
作者：
Ingram DK;de Cabo R
热量限制范式为研究衰老和长寿机制提供了最广泛使用和最有用的工具之一。到目前为止，啮齿动物模型在这些努力中最常使用。经过数十年的调查，有人声称该范式提供了最有力的证据，证明衰老是可塑的。在当前对啮齿动物文献的回顾中，我们提出了质疑延长寿命和健康范式的稳健性的论点。具体来说，需要考虑以下几个问题：（1）CR在什么年龄不再产生效益？ (2) CR 是否可以减轻认知能力下降？ (3) CR 是否有负面影响，包括对骨骼健康、伤口愈合和感染反应的影响？ (4) 喂养时间表有多重要？ （5）CR需要实施多长时间才能生效？ (6) 基因型和性别如何影响CR？ (7) 膳食成分起什么作用？对这些问题的考虑产生了许多警告，这些警告应该指导未来的研究以推动该领域的发展。
The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often in these endeavors. Over decades of investigation, claims have been made that the paradigm produces the most robust demonstration that aging is malleable. In the current review of the rodent literature, we present arguments that question the robustness of the paradigm to increase lifespan and healthspan. Specifically, there are several questions to consider as follows: (1) At what age does CR no longer produce benefits? (2) Does CR attenuate cognitive decline? (3) Are there negative effects of CR, including effects on bone health, wound healing, and response to infection? (4) How important is schedule of feeding? (5) How long does CR need to be imposed to be effective? (6) How do genotype and gender influence CR? (7) What role does dietary composition play? Consideration of these questions produce many caveats that should guide future investigations to move the field forward.
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DOI：
10.4049/jimmunol.1201837
发表时间：
2013-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Clinthorne JF;Beli E;Duriancik DM;Gardner EM
通讯作者：
Gardner EM
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
DOI：
10.1093/gerona/62.4.352
发表时间：
2007-04-01
影响因子：
5.1
作者：
Ayala, Victoria;Naudi, Alba;Pamplona, Reinald
通讯作者：
Pamplona, Reinald
影响因子：
4.7
作者：
Berrigan, D;Perkins, SN;Hursting, SD
通讯作者：
Hursting, SD
影响因子：
3.5
作者：
Bodnar, Marko;Skalicky, Monika;Erben, Reinhold G.
通讯作者：
Erben, Reinhold G.