Preserved Sensitivity to Outcome Value after Lesions of the Basolateral Amygdala
Preserved Sensitivity to Outcome Value after Lesions of the Basolateral Amygdala
复制标题
基底外侧杏仁核损伤后对结果值保持敏感性
DOI：
10.1523/jneurosci.23-20-07702.2003
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Killcross
中科院分区：
文献类型：
--
作者：
Pam Blundell;G. Hall;S. Killcross
最近的工作（Blundell等人，2001; Balleine等人，2003）已经表明杏仁核的基底外侧区域（BLA）在动机显著事件的感觉和激励方面的表征中是重要的。与BLA功能的其他理论一样，这预测了BLA的病变将在食欲巴甫洛夫或工具条件反射后干扰食欲下降。然而，这一假设也预测，BLA病变将没有影响后调节的变化，如果最初的学习是唯一的感觉方面，否则中性事件。这一解释得到了证据的支持，BLA病变对巴甫洛夫自动成形程序中的神经元贬值有显著的不利影响，但使用感觉预处理程序的后处理贬值没有影响。这些结果表明，BLA病变的动物可以保持敏感的结果的动机价值的训练后的变化。
Recent work (Blundell et al., 2001; Balleine et al., 2003) has suggested that the basolateral region of the amygdala (BLA) is important in the representation of the sensory and incentive aspects of motivationally significant events. In common with other theories of function of the BLA, this predicts that lesions of the BLA will interfere with reinforcer devaluation after appetitive Pavlovian or instrumental conditioning. However, this hypothesis also predicts that BLA lesions will be without effect on postconditioning changes in reinforcer value if initial learning is only about the sensory aspects of otherwise neutral events. This interpretation is supported by evidence for significant detrimental effects of BLA lesions on reinforcer devaluation in a Pavlovian autoshaping procedure, but no effect of postconditioning devaluation using a sensory preconditioning procedure. These results demonstrate that animals with BLA lesions can remain sensitive to post-training changes in the motivational value of outcomes.
味觉增强的气味厌恶学习：杏仁核基底外侧复合体和中央核的作用。
影响因子：
1.9
作者：
Hatfield,T;Graham,PW;Gallagher,M
通讯作者：
Gallagher,M