The Golgi and the centrosome: building a functional partnership.

The Golgi and the centrosome: building a functional partnership.
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DOI:
10.1083/jcb.200910001
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发表时间:
2010-03-08
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Colanzi A
Colanzi A
中科院分区:
其他
文献类型:
--
作者:
Sütterlin C;Colanzi A

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哺乳动物高尔基体的特征是在分裂间期靠近中心体的带状结构,在有丝分裂期间从中心体大量分裂和分散。目前尚不清楚高尔基体和中心体之间的这种动态关联是否具有功能意义。我们讨论了最近的研究结果,表明高尔基体与中心体的关系可能对于蛋白质定向运输和中心体定位很重要,这两者都是细胞极化所需的。我们还总结了我们目前的知识高尔基组织和细胞周期进程之间的联系。
The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis. It is not clear whether this dynamic association between the Golgi and centrosome is of functional significance. We discuss recent findings indicating that the Golgi–centrosome relationship may be important for directional protein transport and centrosome positioning, which are both required for cell polarization. We also summarize our current knowledge of the link between Golgi organization and cell cycle progression.
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