Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors.
Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors.
复制标题
个性化fMRI描绘脑肿瘤中保留的功能区域。
DOI：
10.1002/ana.26303
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发表时间：
2022-03
影响因子：
11.2
通讯作者：
Liu, Hesheng
中科院分区：
文献类型：
--
作者：
Cui, Weigang;Wang, Yinyan;Ren, Jianxun;Hubbard, Catherine S.;Fu, Xiaoxuan;Fang, Shengyu;Wang, Danhong;Zhang, Hao;Li, Yang;Li, Luming;Jiang, Tao;Liu, Hesheng
有创性皮层刺激成像和无创神经成像研究的证据表明，脑肿瘤可能保留了脑功能。然而，目前还缺乏一种非侵入性的方法来准确和全面地描述全脑，特别是肿瘤内和肿瘤周围脑组织中的个体特异性功能网络。这项研究的目的是开发一种临床有用的技术，可以绘制肿瘤大脑内的功能区域。我们开发了一种个体特异性功能网络分割方法，使用静息状态功能磁共振成像（rsfMRI）有效地捕获了20例患者肿瘤内部和肿瘤附近的功能网络。我们使用侵入性皮层刺激和任务反应来检查功能图的准确性。我们发现大约33.2%的肿瘤肿块似乎具有功能活性，并与非肿瘤脑区表现出强大的功能连接。通过侵入性皮层刺激作图验证肿瘤附近的功能网络。我们的技术绘制的肿瘤内感觉运动网络可以通过其独特的皮质-小脑连接模式来区分，并且与手部运动诱发的fMRI任务激活一致。此外，在一些患者中，在肿瘤肿块中检测到的认知网络显示出远距离和分布式的功能连接。我们使用rsfMRI绘制个体特异性功能网络的无创方法代表了一种有前途的新工具，用于识别脑肿瘤内部和周围保留功能连接的区域，并可作为肿瘤切除手术患者术前计划的补充。Ann neurol 2022；91:353 - 366
Accumulating evidence from invasive cortical stimulation mapping and noninvasive neuroimaging studies indicates that brain function may be preserved within brain tumors. However, a noninvasive approach to accurately and comprehensively delineate individual‐specific functional networks in the whole brain, especially in brain tissues within and surrounding tumors, is still lacking. The purpose of the study is to develop a clinically useful technique that can map functional regions within tumoral brains. We developed an individual‐specific functional network parcellation approach using resting state functional magnetic resonance imaging (rsfMRI) that effectively captured functional networks within and nearby tumors in 20 patients. We examined the accuracy of the functional maps using invasive cortical stimulation and task response. We found that approximately 33.2% of the tumoral mass appeared to be functionally active and demonstrated robust functional connectivity with non‐tumoral brain regions. Functional networks nearby tumors were validated by invasive cortical stimulation mapping. Intratumoral sensorimotor networks mapped by our technique could be distinguished by their distinct cortico‐cerebellar connectivity patterns and were consistent with hand movement evoked fMRI task activations. Furthermore, in some patients, cognitive networks that were detected in the tumor mass showed long‐distance and distributed functional connectivity. Our noninvasive approach to mapping individual‐specific functional networks using rsfMRI represents a promising new tool for identifying regions with preserved functional connectivity within and surrounding brain tumors, and could be used as a complement to presurgical planning for patients undergoing tumor resection surgery. ANN NEUROL 2022;91:353–366
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影响因子：
9.8
作者：
Holmes, Avram J.;Hollinshead, Marisa O.;O'Keefe, Timothy M.;Petrov, Victor I.;Fariello, Gabriele R.;Wald, Lawrence L.;Fischl, Bruce;Rosen, Bruce R.;Mair, Ross W.;Roffman, Joshua L.;Smoller, Jordan W.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
16.2
作者：
Mueller S;Wang D;Fox MD;Yeo BT;Sepulcre J;Sabuncu MR;Shafee R;Lu J;Liu H
通讯作者：
Liu H
在增强胶质母细胞瘤的增强和非增强部分的肿瘤浸润：与组织病理学的相关性。
影响因子：
3.7
作者：
Eidel O;Burth S;Neumann JO;Kieslich PJ;Sahm F;Jungk C;Kickingereder P;Bickelhaupt S;Mundiyanapurath S;Bäumer P;Wick W;Schlemmer HP;Kiening K;Unterberg A;Bendszus M;Radbruch A
通讯作者：
Radbruch A
DOI：
10.1093/brain/aws041
发表时间：
2012-04
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Otten ML;Mikell CB;Youngerman BE;Liston C;Sisti MB;Bruce JN;Small SA;McKhann GM 2nd
通讯作者：
McKhann GM 2nd