Motor deficits correlate with resting state motor network connectivity in patients with brain tumours.
Motor deficits correlate with resting state motor network connectivity in patients with brain tumours.
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DOI：
10.1093/brain/aws041
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
McKhann GM 2nd
中科院分区：
文献类型：
--
作者：
Otten ML;Mikell CB;Youngerman BE;Liston C;Sisti MB;Bruce JN;Small SA;McKhann GM 2nd
虽然初级运动皮层中或邻近初级运动皮层的肿瘤会导致运动无力，但额叶或顶叶其他部位的肿瘤如何影响虚弱患者的功能连接尚不清楚。我们假设，运动中心分布式网络中功能连接的减弱与大脑肿块受试者的运动无力有关。此外，我们假设半球间的连接最容易受到功能连接的微妙破坏。我们使用无任务功能磁共振成像连接来探测对照受试者和脑肿瘤患者的运动网络（n = 22）。使用控制数据集，我们基于手部运动旋钮在初级运动皮层中的解剖位置，开发了一种自动检测运动网络中关键节点的方法，包括初级运动皮层、辅助运动区、运动前区和顶上小叶。然后，我们计算了对照受试者以及有或没有脑肿块的患者运动网络节点之间的功能连接。我们利用这些信息构建加权、无向图，然后将其与感兴趣的变量进行比较，包括运动任务的表现、凹槽钉板。在所识别的所有双边节点之间的运动网络中观察到强连接性，特别是在初级运动皮层和辅助运动区之间。与力量正常的受试者相比，运动无力的受试者中观察到连接性降低（P < 0.001）。这种差异主要是由于初级运动皮层之间的半球间连接（P < 0.05）和左侧初级运动皮层与右侧运动前区之间的半球间连接（P < 0.05）以及其他运动前区连接的减少所致。然而，在没有运动无力的受试者中，在凹槽钉板上的表现与半球间的连接性无关，而是与左手和右手的左前运动区和左辅助运动区之间的连接性呈负相关（P<0.01）。最后，对两名在脑肿瘤手术后经历严重虚弱的受试者进行了纵向随访，康复的受试者在随访中显示出其运动网络的重建。持续虚弱的受试者没有重建他的运动网络。不涉及初级运动结构的脑肿瘤患者的运动无力与运动功能网络内的连接性下降有关，特别是半球间连接。随着受试者变弱，运动网络也会变弱，并且在运动恢复期间可能会再次变强。
While a tumour in or abutting primary motor cortex leads to motor weakness, how tumours elsewhere in the frontal or parietal lobes affect functional connectivity in a weak patient is less clear. We hypothesized that diminished functional connectivity in a distributed network of motor centres would correlate with motor weakness in subjects with brain masses. Furthermore, we hypothesized that interhemispheric connections would be most vulnerable to subtle disruptions in functional connectivity. We used task-free functional magnetic resonance imaging connectivity to probe motor networks in control subjects and patients with brain tumours (n = 22). Using a control dataset, we developed a method for automated detection of key nodes in the motor network, including the primary motor cortex, supplementary motor area, premotor area and superior parietal lobule, based on the anatomic location of the hand-motor knob in the primary motor cortex. We then calculated functional connectivity between motor network nodes in control subjects, as well as patients with and without brain masses. We used this information to construct weighted, undirected graphs, which were then compared to variables of interest, including performance on a motor task, the grooved pegboard. Strong connectivity was observed within the identified motor networks between all nodes bilaterally, and especially between the primary motor cortex and supplementary motor area. Reduced connectivity was observed in subjects with motor weakness versus subjects with normal strength (P < 0.001). This difference was driven mostly by decreases in interhemispheric connectivity between the primary motor cortices (P < 0.05) and between the left primary motor cortex and the right premotor area (P < 0.05), as well as other premotor area connections. In the subjects without motor weakness, however, performance on the grooved pegboard did not relate to interhemispheric connectivity, but rather was inversely correlated with connectivity between the left premotor area and left supplementary motor area, for both the left and the right hands (P < 0.01). Finally, two subjects who experienced severe weakness following surgery for their brain tumours were followed longitudinally, and the subject who recovered showed reconstitution of her motor network at follow-up. The subject who was persistently weak did not reconstitute his motor network. Motor weakness in subjects with brain tumours that do not involve primary motor structures is associated with decreased connectivity within motor functional networks, particularly interhemispheric connections. Motor networks become weaker as the subjects become weaker, and may become strong again during motor recovery.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Kochunov, P.;Coyle, T.;Lancaster, J.;Robin, D. A.;Hardies, J.;Kochunov, V.;Bartzokis, G.;Stanley, J.;Royall, D.;Schlosser, A. E.;Null, M.;Fox, P. T.
通讯作者：
Fox, P. T.
影响因子：
11
作者：
Duffau, H;Capelle, L;Van Effenterre, R
通讯作者：
Van Effenterre, R
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.