Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.
Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.
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DOI：
10.1016/j.neuroscience.2018.09.036
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发表时间：
2019-05-21
期刊：
影响因子：
3.3
通讯作者：
Salvi R
中科院分区：
文献类型：
--
作者：
Auerbach BD;Radziwon K;Salvi R
听觉亢进的中枢增益模型认为，听觉输入的缺失会导致中枢听觉系统神经元增益的不适应增加，从而导致声诱发活动的过度放大和过度的响度感知。尽管这个模型很有吸引力，也有支持它的证据，但对中心增益理论的一项关键测试要求，声音诱发活动的变化与响度的感知变化有明确的联系。在这里，我们结合了一个操作性条件反射任务，该任务使用受试者对听觉刺激的反应时间来产生可靠的响度增长测量，并结合了清醒的行为表现型动物的听觉皮层和下丘的慢性电生理记录。通过这种方式，我们可以直接将同一只动物的声音编码的神经生理测量与响度感知的日常评估联系起来。我们用水杨酸诱导的听力损失和听觉亢进模型验证了这种新的心理物理-电生理范式，因为高剂量水杨酸钠可靠地诱导暂时性听力损失、神经亢进和听觉感知中断，如耳鸣和听觉亢进。水杨酸引起响度增长的平行变化，并引起与暂时性听力损失和听觉亢进一致的反应强度功能。最重要的是，我们发现水杨酸介导的响度增长和声诱发活动的变化在个体动物中是相关的。这些结果为听觉亢进的中心增益模型提供了强有力的支持，并证明了使用实验设计的实用性，该实验设计允许对受试者内部的行为和电生理测量进行比较，从而使受试者之间的可变性成为一种优势而不是限制。
The central gain model of hyperacusis proposes that loss of auditory input can result in maladaptive neuronal gain increases in the central auditory system, leading to the over-amplification of sound-evoked activity and excessive loudness perception. Despite the attractiveness of this model, and supporting evidence for it, a critical test of the central gain theory requires that changes in sound-evoked activity be explicitly linked to perceptual alterations of loudness. Here we combined an operant conditioning task that uses a subject’s reaction time to auditory stimuli to produce reliable measures of loudness growth with chronic electrophysiological recordings from the auditory cortex and inferior colliculus of awake, behaviorally-phenotyped animals. In this manner, we could directly correlate daily assessments of loudness perception with neurophysiological measures of sound encoding within the same animal. We validated this novel psychophysical-electrophysiological paradigm with a salicylate-induced model of hearing loss and hyperacusis, as high doses of sodium salicylate reliably induce temporary hearing loss, neural hyperactivity, and auditory perceptual disruptions like tinnitus and hyperacusis. Salicylate induced parallel changes to loudness growth and evoked response-intensity functions consistent with temporary hearing loss and hyperacusis. Most importantly, we found that salicylate-mediated changes in loudness growth and sound-evoked activity were correlated within individual animals. These results provide strong support for the central gain model of hyperacusis and demonstrate the utility of using an experimental design that allows for within-subject comparison of behavioral and electrophysiological measures, thereby making inter-subject variability a strength rather than a limitation.
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影响因子：
2.8
作者：
Jiang C;Luo B;Manohar S;Chen GD;Salvi R
通讯作者：
Salvi R
影响因子：
3.3
作者：
Chen GD;Sheppard A;Salvi R
通讯作者：
Salvi R
影响因子：
16.2
作者：
Chambers AR;Resnik J;Yuan Y;Whitton JP;Edge AS;Liberman MC;Polley DB
通讯作者：
Polley DB
DOI：
10.1080/010503999424653
发表时间：
1999-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
Anari, M;Axelsson, A;Magnusson, L
通讯作者：
Magnusson, L
影响因子：
1.4
作者：
Lanting, C. P.;De Kleine, E.;Van Dijk, P.
通讯作者：
Van Dijk, P.