Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.
Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.
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神经胶质瘤患者静息状态网络的评估：未受影响一侧的连接变化及其与认知功能的关系。
DOI：
10.1371/journal.pone.0118072
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wakabayashi T
中科院分区：
文献类型：
--
作者：
Maesawa S;Bagarinao E;Fujii M;Futamura M;Motomura K;Watanabe H;Mori D;Sobue G;Wakabayashi T
在这项研究中，我们调查了位于左半球的胶质瘤患者静息状态网络（RSN）的变化及其与认知功能的关系。我们假设长距离连接，特别是大脑半球之间的连接，会受到肿瘤的影响。我们进一步假设，这些变化将与神经胶质瘤患者中观察到的认知变化相关或反映认知变化。在分析中使用了来自12名患者和12名健康对照的静息状态功能MRI数据集。采用二元回归分析研究了肿瘤对默认模式网络（DMN）、执行控制网络（ECN）和显著性网络（SN）的影响。同时比较两组的神经心理测验（WAIS-III和WMS-R）得分。与健康对照组相比，患者组显示腹侧DMN的右角回/顶下叶和左侧ECN的背外侧前额叶皮层的功能连接显著减少，而右侧ECN的连接显著增加，观察到右侧顶叶。右侧ECN的连接变化与空间记忆相关，而左侧ECN的连接变化与注意力相关。腹侧DMN的连接变化与注意力、工作记忆、完整智商和语言智商测量相关。虽然肿瘤位于大脑左侧，但在对侧观察到连通性的变化。此外，这些变化与认知功能的某些方面相关，表明胶质瘤患者即使在没有主要症状或在主要症状发作之前也可能发生认知变化。静息状态网络的评估可能有助于我们对胶质瘤病例脑功能的hodological理解。
In this study, we investigated changes in resting state networks (RSNs) in patients with gliomas located in the left hemisphere and its relation to cognitive function. We hypothesized that long distance connection, especially between hemispheres, would be affected by the presence of the tumor. We further hypothesized that these changes would correlate with, or reflect cognitive changes observed in patients with gliomas. Resting state functional MRI datasets from 12 patients and 12 healthy controls were used in the analysis. The tumor’s effect on three well-known RSNs including the default mode network (DMN), executive control network (ECN), and salience network (SN) identified using independent component analysis were investigated using dual regression analysis. Scores of neuropsychometric testing (WAIS-III and WMS-R) were also compared. Compared to the healthy control group, the patient group showed significant decrease in functional connectivity in the right angular gyrus/inferior parietal lobe of the ventral DMN and in the dorsolateral prefrontal cortex of the left ECN, whereas a significant increase in connectivity in the right ECN was observed in the right parietal lobe. Changes in connectivity in the right ECN correlated with spatial memory, while that on the left ECN correlated with attention. Connectivity changes in the ventral DMN correlated with attention, working memory, full IQ, and verbal IQ measures. Although the tumors were localized in the left side of the brain, changes in connectivity were observed in the contralateral side. Moreover, these changes correlated with some aspects of cognitive function indicating that patients with gliomas may undergo cognitive changes even in the absence of or before the onset of major symptoms. Evaluation of resting state networks could be helpful in advancing our hodological understanding of brain function in glioma cases.
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