Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi
Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi
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深度分化的复杂多细胞真菌之间无与伦比的分子聚合水平
DOI：
10.1093/molbev/msaa077
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发表时间：
2020
影响因子：
10.7
通讯作者：
Pupko, Tal
中科院分区：
文献类型：
--
作者：
Merényi, Zsolt;Prasanna, Arun N;Wang, Zheng;Kovács, Károly;Hegedüs, Botond;Bálint, Balázs;Papp, Balázs;Townsend, Jeffrey P;Nagy, László G;Pupko, Tal
趋同进化在自然界中普遍存在，但人们对各种约束和自然选择如何限制可进化表型的多样性知之甚少。在这里，我们分析了整个子实体发育的转录组，以了解在两个最大的分支真菌-蘑菇-和盘菌亚门复杂的多细胞性的独立进化。尽管这些进化枝之间的差异大于650 My，但我们发现，非常相似的基因组已经收敛地被选择用于复杂的多细胞性，随后通过复制扩展其基因家族。超过82%的共享多细胞相关基因家族在两个分支中扩展，这表明在基因家族水平上也存在高度趋同。这种收敛加上丰富的推断剧目的多细胞相关基因在最近的共同祖先的Agarico和盘菌亚门，一致的假设，即祖先真菌基因组的编码能力可能促进了复杂的多细胞性的重复进化。我们解释这个剧目作为一个指示的进化倾向的真菌祖先进化复杂的多细胞子实体。我们的工作表明，进化趋同不仅可能发生在生物体密切相关或处于相似的选择压力下时，而且也可能发生在祖先基因组库使某些进化轨迹比其他轨迹更有可能时，即使跨越大的系统发育距离。
Convergent evolution is pervasive in nature, but it is poorly understood how various constraints and natural selection limit the diversity of evolvable phenotypes. Here, we analyze the transcriptome across fruiting body development to understand the independent evolution of complex multicellularity in the two largest clades of fungi—the Agarico- and Pezizomycotina. Despite >650 My of divergence between these clades, we find that very similar sets of genes have convergently been co-opted for complex multicellularity, followed by expansions of their gene families by duplications. Over 82% of shared multicellularity-related gene families were expanding in both clades, indicating a high prevalence of convergence also at the gene family level. This convergence is coupled with a rich inferred repertoire of multicellularity-related genes in the most recent common ancestor of the Agarico- and Pezizomycotina, consistent with the hypothesis that the coding capacity of ancestral fungal genomes might have promoted the repeated evolution of complex multicellularity. We interpret this repertoire as an indication of evolutionary predisposition of fungal ancestors for evolving complex multicellular fruiting bodies. Our work suggests that evolutionary convergence may happen not only when organisms are closely related or are under similar selection pressures, but also when ancestral genomic repertoires render certain evolutionary trajectories more likely than others, even across large phylogenetic distances.
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DOI：
--
发表时间：
2007
期刊：
Current Genetics 51
影响因子：
--
作者：
Miyazaki Y;Kaneko S;Sunagawa M;Shishido K;Yamazaki T;Nakamura M;Babasaki K.
通讯作者：
Babasaki K.
使用定量性状基因座和突变积累数据进行选择的测试
影响因子：
3.3
作者：
D. P. Rice;J. Townsend
通讯作者：
J. Townsend
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
影响因子：
9.2
作者：
Wirthlin, Morgan;Lima, Nicholas C. B.;Mello, Claudio V.
通讯作者：
Mello, Claudio V.
影响因子：
4.5
作者：
Traeger S;Altegoer F;Freitag M;Gabaldon T;Kempken F;Kumar A;Marcet-Houben M;Pöggeler S;Stajich JE;Nowrousian M
通讯作者：
Nowrousian M