The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats.
The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats.
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DOI：
10.1186/1472-6882-12-53
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发表时间：
2012-04-25
影响因子：
--
通讯作者：
Guo D
中科院分区：
文献类型：
--
作者：
Chen H;Yin J;Deng Y;Yang M;Xu L;Teng F;Li D;Cheng Y;Liu S;Wang D;Zhang T;Wu W;Liu X;Guan S;Jiang B;Guo D
尽管有许多药物可用于治疗高血压，但高血压引起的器官损害尚未得到解决。本研究的目的是探讨人参皂苷 Rg1 (Rg1) 对自发性高血压大鼠 (SHR) 血管重塑和器官损伤的保护作用。雄性SHR每天腹腔注射5、10或20mg/kg Rg1，持续1个月。使用接受载体（盐水）的 SHR 或 Wistar-Kyoto 大鼠（WKY）作为对照。采用血压检测、病理染色、透射电镜、免疫组化等方法阐明Rg1的保护作用。对照SHR大鼠和Rg1处理的SHR大鼠之间的血压没有差异，但根据组织病理学和超微结构检测，Rg1通过降低管腔直径和减少中层厚度来改善主动脉向外重塑。 Rg1 还可以保护视网膜血管免受免疫组织化学检测检测到的向内重塑。此外，Rg1 可减轻目标心脏和肾脏损伤，改善心脏和肾小球结构。这些结果表明，Rg1 对血管结构具有有益的影响，并进一步防止高血压引起的器官损伤。这些发现也为治疗高血压并发症开辟了一种新颖且有前途的方法。
Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside Rg1 (Rg1) against vascular remodeling and organ damage in spontaneously hypertensive rats (SHR). Male SHR were treated with 5, 10 or 20 mg/kg Rg1 through intraperitoneal injection per day for 1 month. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (saline) was used as control. Blood pressure detection and pathological stain, transmission electron microscope, immunohistochemical assay were used to elucidate the protection of Rg1. Blood pressures were not different between control SHR rats and Rg1 treated SHR rats, but Rg1 improved the aortic outward remodeling by lowering the lumen diameter and reducing the media thickness according the histopathological and ultrastructural detections. Rg1 also protected the retinal vessels against inward remodeling detected by immunohistochemical assay. Furthermore, Rg1 attenuated the target heart and kidney damage with improvement on cardiac and glomerular structure. These results suggested that Rg1 held beneficial effects on vascular structure and further protected against the organ-damage induced by hypertension. These findings also paved a novel and promising approach to the treatment of hypertensive complications.
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影响因子：
6.1
作者：
Park, WH;Lee, SK;Kim, CH
通讯作者：
Kim, CH
影响因子：
3.2
作者：
Mercier, Nathalie;Labat, Carlos;Lacolley, Patrick
通讯作者：
Lacolley, Patrick
影响因子：
4.9
作者：
Leenen, FHH;Yuan, BX
通讯作者：
Yuan, BX
影响因子：
8.2
作者：
Ma, Zeng-chun;Gao, Yue;Wang, Sheng-qi
通讯作者：
Wang, Sheng-qi
影响因子：
37.8
作者：
Sengupta, S;Toh, SA;Fan, TPD
通讯作者：
Fan, TPD