MRI analysis in temporal lobe epilepsy: cortical thinning and white matter disruptions are related to side of seizure onset.
MRI analysis in temporal lobe epilepsy: cortical thinning and white matter disruptions are related to side of seizure onset.
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DOI：
10.1111/j.1528-1167.2011.03278.x
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发表时间：
2011-12
期刊：
影响因子：
5.6
通讯作者：
McDonald CR
中科院分区：
文献类型：
--
作者：
Kemmotsu N;Girard HM;Bernhardt BC;Bonilha L;Lin JJ;Tecoma ES;Iragui VJ;Hagler DJ Jr;Halgren E;McDonald CR
过去的研究报道，与右颞叶癫痫（TLE）患者相比，左颞叶癫痫患者的脑结构异常更为广泛，但这些差异的概况仍然未知。本研究调查了TLE患者皮质变薄、白色物质受损、癫痫变量和癫痫发作侧之间的关系。我们对18例左侧TLE（LTLE）、18例右侧TLE（RTLE）和36例对照者进行了弥散张量成像纤维束成像和皮质厚度分析。我们研究了脑结构异常、发作侧、发作年龄和病程之间的关系。TLE组显示皮质变薄和白色物质受损，主要发生在癫痫发作的同侧。相对于RTLE，LTLE患者表现出更广泛的异常，特别是在白色物质纤维束。白色物质完整性的更大损害与癫痫发作的早期年龄相关，而皮质变薄与疾病持续时间轻微相关。这些数据支持以前的研究结果显示，LTLE更大的结构损害比RTLE，并表明，机制可能是不统一的灰和白色物质损害的LTLE和RTLE患者。这些结果可能表明，LTLE是不同于RTLE，可能是由于更大的脆弱性，左半球的早期损伤和癫痫发作的渐进性影响。
Past studies reported more widespread structural brain abnormalities in patients with left compared to right temporal lobe epilepsy (TLE), but the profile of these differences remain unknown. This study investigated the relationship between cortical thinning, white matter compromise, epilepsy variables, and the side of seizure onset, in patients with TLE. We performed diffusion tensor imaging tractography and cortical thickness analyses of 18 patients with left TLE (LTLE), 18 patients with right TLE (RTLE), and 36 controls. We investigated the relationship between brain structural abnormalities, side of seizure onset, age of seizure onset, and disease duration. TLE groups displayed cortical thinning and white matter compromise, predominately on the side ipsilateral to the seizure onset. Relative to RTLE, patients with LTLE showed more widespread abnormalities, particularly in white matter fiber tracts. Greater compromise in white matter integrity was associated with earlier age of seizure onset, while cortical thinning was marginally associated with disease duration. These data support previous findings of LTLE showing greater structural compromise than RTLE, and suggest that mechanisms may not be uniform for gray and white matter compromise in patients with LTLE and RTLE. These results may indicate that LTLE is different than RTLE, possibly due to greater vulnerability of the left hemisphere to early injury and the progressive effects of seizures.
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影响因子：
5.6
作者：
Bonilha L;Edwards JC;Kinsman SL;Morgan PS;Fridriksson J;Rorden C;Rumboldt Z;Roberts DR;Eckert MA;Halford JJ
通讯作者：
Halford JJ
影响因子：
5.7
作者：
Bernasconi, N;Duchesne, S;Bernasconi, A
通讯作者：
Bernasconi, A
影响因子：
5.6
作者：
Hermann, B;Seidenberg, M;Magnotta, V
通讯作者：
Magnotta, V
影响因子：
9.9
作者：
Bernasconi, N;Natsume, J;Bernasconi, A
通讯作者：
Bernasconi, A
DOI：
10.3174/ajnr.a1650
发表时间：
2009-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ahmadi ME;Hagler DJ Jr;McDonald CR;Tecoma ES;Iragui VJ;Dale AM;Halgren E
通讯作者：
Halgren E