Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?
Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?
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DOI：
10.3945/ajcn.2008.27139
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Victora CG
中科院分区：
文献类型：
--
作者：
Adair LS;Martorell R;Stein AD;Hallal PC;Sachdev HS;Prabhakaran D;Wills AK;Norris SA;Dahly DL;Lee NR;Victora CG
背景：促进营养不良儿童的追赶性生长对健康有益，但最近的证据表明，儿童体重加速增加会增加成人患慢性病的风险。目的：我们旨在确定出生体重（BW）和儿童中期体重增加与年轻人血压（BP）的关系。设计：我们汇集了来自巴西、危地马拉、印度、菲律宾和南非出生队列的数据。我们使用条件体重（CW），即当前体重对先前体重回归的残差，来表示从0到12、12到24、24到48个月以及48个月到成年期的预期体重增加的偏差。在调整成人体重指数（BMI）和身高前后分别建立成人血压和高血压前期或高血压风险（P/HTN）模型。检测出生时胎龄小的CWs的相互作用。结果：较高的CWs与血压升高和P/HTN的几率相关，其系数与每个CW对成人BMI的贡献成正比。经成人身高和BMI调整后，儿童CW与成人血压无相关性，但BW的1 SD与收缩压降低0.5 mm Hg和P/HTN发生率降低9%相关。出生时体重和连续波与收缩压和P/HTN的相关性在出生时体重正常的成年人和出生时体重正常的成年人之间没有差异，但出生时48月龄较高的连续波与出生时舒张压升高有关。结论：任何年龄的体重增加都与成人血压升高有关，但婴儿期和幼儿期体重增加较快并不比其他年龄的体重增加造成更高的风险。
Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. Objective: We aimed to determine how birth weight (BW) and weight gain to midchildhood relate to blood pressure (BP) in young adults. Design: We pooled data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa. We used conditional weight (CW), a residual of current weight regressed on prior weights, to represent deviations from expected weight gain from 0 to 12, 12 to 24, 24 to 48 mo, and 48 mo to adulthood. Adult BP and risk of prehypertension or hypertension (P/HTN) were modeled before and after adjustment for adult body mass index (BMI) and height. Interactions of CWs with small size-for-gestational age (SGA) at birth were tested. Results: Higher CWs were associated with increased BP and odds of P/HTN, with coefficients proportional to the contribution of each CW to adult BMI. Adjusted for adult height and BMI, no child CW was associated with adult BP, but 1 SD of BW was related to a 0.5-mm Hg lower systolic BP and a 9% lower odds of P/HTN. BW and CW associations with systolic BP and P/HTN were not different between adults born SGA and those with normal BW, but higher CW at 48 mo was associated with higher diastolic BP in those born SGA. Conclusions: Greater weight gain at any age relates to elevated adult BP, but faster weight gains in infancy and young childhood do not pose a higher risk than do gains at other ages.
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影响因子：
8.3
作者：
Eriksson, J;Forsén, T;Barker, D
通讯作者：
Barker, D
影响因子：
2.5
作者：
Martorell, Reynaldo;Ho, Teresa J.
通讯作者：
Ho, Teresa J.
影响因子：
8.9
作者：
Monteiro, POA;Victora, CG
通讯作者：
Victora, CG
影响因子：
7.7
作者：
Barker, DJP;Eriksson, JG;Osmond, C
通讯作者：
Osmond, C
DOI：
10.1046/j.1440-6047.2002.00258.x
发表时间：
2002-01-01
影响因子：
1.3
作者：
Deurenberg, P;Deurenberg-Yap, M
通讯作者：
Deurenberg-Yap, M