A model of efficiency: stress tolerance by Streptococcus mutans.
A model of efficiency: stress tolerance by Streptococcus mutans.
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DOI：
10.1099/mic.0.2008/023770-0
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发表时间：
2008-11
期刊：
影响因子：
2.8
通讯作者：
Burne, Robert A.
中科院分区：
文献类型：
--
作者：
Lemos, Jose A.;Burne, Robert A.
变形链球菌（一种通常与人类龋齿相关的细菌病原体）的完整基因组序列于2002年发表。精简的基因组（2.03Mb）揭示了一种生物体，它很好地适应了牙齿表面多物种生物膜中与宿主相关的存在;一个动态的环境，经历了快速和大量的环境波动。然而，S.变形杆菌缺乏许多传感系统和替代的σ因子，细菌通常使用这些系统和因子来协调基因表达以响应压力和环境变化。在过去的七年中，功能基因组学和蛋白质组学增强了我们对S。mutans已经整合了应激调节子和全局转录调节子，以确保在口腔中的持久性并利用有利于龋齿发展的条件的方式将对环境波动的响应与毒力的调节整合在一起。在这里，我们强调的进展解剖的应力调节子的S。变形链球菌及其与发病的密切关系。
The complete genome sequence of Streptococcus mutans, a bacterial pathogen commonly associated with human dental caries, was published in 2002. The streamlined genome (2.03Mb) revealed an organism that was well adapted to its obligately host-associated existence in multispecies biofilms on tooth surfaces; a dynamic environment that undergoes rapid and substantial environmental fluctuations. However, S. mutans lacks many of the sensing systems and alternative sigma factors that bacteria often use to coordinate gene expression in response to stress and changes in their environment. Over the past seven years, functional genomics and proteomics have enhanced our understanding of how S. mutans has integrated the stress regulon and global transcriptional regulators to integrate responses to environmental fluctuations with modulation of virulence in a way that ensures persistence in the oral cavity and capitalizes on conditions that are favorable for the development of dental caries. Here, we highlight advances on dissection of the stress regulon of S. mutans and its intimate interrelationship with pathogenesis.
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影响因子：
3.2
作者：
Biswas, Indranil;Drake, Laura;Biswas, Saswati
通讯作者：
Biswas, Saswati
DOI：
10.1073/pnas.202353699
发表时间：
2002-10-15
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.2
作者：
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影响因子：
3.6
作者：
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通讯作者：
Quivey, RG
影响因子：
3.2
作者：
Biswas, S;Biswas, I
通讯作者：
Biswas, I