Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer.
Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer.
复制标题
习惯性饮酒对 II-III 期结直肠癌平均红细胞体积预后意义的影响
DOI：
10.3389/fonc.2021.681406
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Liu Q;Yang Y;Li X;Zhang S
阐明平均红细胞体积（MCV）的预后意义，以及习惯性饮酒对II-III期结直肠癌（CRC）的影响。MCV有可能成为一种理想的预后生物标志物并投入临床应用。然而，很少有研究探讨是否习惯性饮酒，大大增加了MCV值会影响MCV的预后作用。从2012年1月至2013年12月期间复旦大学上海肿瘤防治中心（FUSCC）的CRC数据库中确定合格患者。采用Kaplan-Meier法进行生存分析，以评估生存时间分布，并采用对数秩检验确定生存差异。建立单因素和多因素考克斯比例风险模型计算不同预后因素的风险比。2012年1月至2013年12月期间，从FUSCC中共确定了694例诊断为II-III期CRC的患者。与MCV正常相比，治疗前MCV低与总体死亡风险增加72.0%独立相关（HR = 1.720，95%CI =1.028-2.876，P =0.039，以MCV正常为参照）。然而，在习惯性饮酒的患者中，在校正其他已知的预后因素后，治疗前MCV与死亡率（P = 0.02）和肿瘤复发率（P = 0.002）呈正相关。在没有习惯性饮酒的CRC患者中，治疗前MCV水平低（<80 fL）是预后不良的预测因子。然而，在习惯性饮酒的患者中，治疗前MCV显示出相反的预后作用，这将引发许多基础研究来阐明其背后的机制。
To elucidate the prognostic significance of mean corpuscular volume (MCV), with implications of habitual alcohol intake in stage II-III colorectal cancer (CRC). MCV had the potential to become an ideal prognostic biomarker and be put into clinical application. Few studies, however, have explored whether habitual alcohol intake which greatly increased the value of MCV would affect the prognostic role of MCV. Eligible patients were identified from the CRC database of Fudan University Shanghai Cancer Center (FUSCC) between January 2012 and December 2013. Survival analyses were constructed using the Kaplan–Meier method to evaluate the survival time distribution, and the log-rank test was used to determine the survival differences. Univariate and multivariate Cox proportional hazard models were built to calculate the hazard ratios of different prognostic factors. A total of 694 patients diagnosed with stage II-III CRC between January 2012 and December 2013 were identified from FUSCC. Low pretreatment MCV was independently associated with 72.0% increased risk of overall mortality compared with normal MCV (HR = 1.720, 95%CI =1.028-2.876, P =0.039, using normal MCV as the reference). In patients with habitual alcohol intake, however, pretreatment MCV positively correlated with the mortality (P = 0.02) and tumor recurrence (P = 0.002) after adjusting for other known prognostic factors. In CRC patients without habitual alcohol intake, low (<80 fL) level of pretreatment MCV was a predictor of poor prognosis. In patients with habitual alcohol intake, however, pretreatment MCV showed the opposite prognostic role, which would elicit many fundamental studies to elucidate the mechanisms behind.
登录
查看更多内容
影响因子：
6.3
作者：
Chung, Wei-Sheng;Lin, Chun-Liang;Kao, Chia-Hung
通讯作者：
Kao, Chia-Hung
影响因子：
2.8
作者：
Parsons, Henrique A.;Delgado-Guay, Marvin Omar;Bruera, Eduardo
通讯作者：
Bruera, Eduardo
影响因子：
39.2
作者：
Cho, EY;Smith-Warner, SA;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
7.1
作者：
Cravo, ML;Gloria, LM;Mira, FC
通讯作者：
Mira, FC
影响因子：
6
作者：
GRANT, BF
通讯作者：
GRANT, BF