Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis.
Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis.
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DOI：
10.1038/emboj.2012.192
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发表时间：
2012-08-15
期刊：
影响因子：
11.4
通讯作者：
Ventura, Juan-Jose
中科院分区：
文献类型：
--
作者：
Oeztuerk-Winder, Feride;Guinot, Anna;Ochalek, Anna;Ventura, Juan-Jose
控制肺稳态和再生的细胞和分子机制仍然知之甚少。已经提出，小鼠肺中存在细胞群体，其具有在体内平衡中或响应于病毒感染而分化成所有主要肺细支气管肺泡上皮细胞类型的潜力。一个新的E-Cad/Lgr 6+推定干细胞群体已被分离出来，并从人肺中无限扩增，具有自我更新能力和体外和体内分化的潜力。最近，一个假定的人肺干细胞群体被认为是c-Kit+。与整合素-α6+或c-Kit+细胞不同，在肾囊中注射E-Cad/Lgr 6+单细胞产生分化的细支气管肺泡组织，同时保持自我更新，因为它们可以在肾囊下或肺中进行连续移植。此外，还发现了一个涉及p38α通路、p53激活和miR-17-92簇调控的信号网络。这种信号轴的适当交叉调节的破坏可能参与促进人类肺部疾病。
The cellular and molecular mechanisms that control lung homeostasis and regeneration are still poorly understood. It has been proposed that a population of cells exists in the mouse lung with the potential to differentiate into all major lung bronchioalveolar epithelium cell types in homeostasis or in response to virus infection. A new population of E-Cad/Lgr6+ putative stem cells has been isolated, and indefinitely expanded from human lungs, harbouring both, self-renewal capacity and the potency to differentiate in vitro and in vivo. Recently, a putative population of human lung stem cells has been proposed as being c-Kit+. Unlike Integrin-α6+ or c-Kit+ cells, E-Cad/Lgr6+ single-cell injections in the kidney capsule produce differentiated bronchioalveolar tissue, while retaining self-renewal, as they can undergo serial transplantations under the kidney capsule or in the lung. In addition, a signalling network involving the p38α pathway, the activation of p53 and the regulation of the miR-17-92 cluster has been identified. Disruption of the proper cross-regulation of this signalling axis might be involved in the promotion of human lung diseases.
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影响因子：
64.5
作者：
Kumar PA;Hu Y;Yamamoto Y;Hoe NB;Wei TS;Mu D;Sun Y;Joo LS;Dagher R;Zielonka EM;Wang de Y;Lim B;Chow VT;Crum CP;Xian W;McKeon F
通讯作者：
McKeon F
Sox17 促进细胞周期进程并抑制 TGF-β/Smad3 信号传导以启动呼吸道上皮中的祖细胞行为。
影响因子：
3.7
作者：
Lange AW;Keiser AR;Wells JM;Zorn AM;Whitsett JA
通讯作者：
Whitsett JA
影响因子：
2.7
作者：
Lu, Yun;Thomson, J. Michael;Hogan, Brigid L. M.
通讯作者：
Hogan, Brigid L. M.
影响因子：
4.6
作者：
Martis, PC;Whitsett, JA;Ikegami, M
通讯作者：
Ikegami, M
影响因子：
30.8
作者：
Hui, Lijian;Bakiri, Latifa;Wagner, Erwin F.
通讯作者：
Wagner, Erwin F.