Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina
Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina
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DNA结合蛋白抑制剂（Id3）在小鼠视网膜中的发育表达模式和定位
DOI：
10.1097/00001756-200505120-00004
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发表时间：
2005
期刊：
影响因子：
1.7
通讯作者：
Yip Hk
中科院分区：
文献类型：
--
作者：
S. Yeung;Yip Hk
Id 3（inhibitor of DNA binding/differentiation）是Id helix-loop-helix蛋白家族的一员，长期以来一直被研究为增殖的正调节剂和分化的负调节剂。在这项研究中，我们研究了Id 3在出生后和成年小鼠视网膜中的表达模式和细胞表型。Id 3主要表达于出生后早期的内层视网膜。从出生后发育后期到成年期，Id 3的表达仅限于神经节细胞层和内核层。共定位分析显示Id 3阳性细胞为视网膜神经节细胞和无长突细胞。Id 3的差异表达谱为阐明其在视网膜发育中的可能作用提供了基础。
Id3 (inhibitor of DNA binding/differentiation), a member of the Id helix–loop–helix protein family, has long been studied as a positive regulator of proliferation and a negative regulator of differentiation. In this study, we examined the expression pattern and cellular phenotypes of Id3 in postnatal and adult mouse retina. Id3 was mainly expressed in the early postnatal inner retina. From the late postnatal development towards adulthood, Id3 expression was confined to the ganglion cell layer and the inner nuclear layer. Colocalization analysis showed that Id3 positive cells were identified as retinal ganglion cells and amacrine cells. The differential expression profiles of Id3 provide the groundwork for the elucidation of its possible role in retinal development.
DOI：
10.1073/pnas.88.5.1815
发表时间：
1991-03-01
影响因子：
11.1
作者：
CHRISTY, BA;SANDERS, LK;NATHANS, D
通讯作者：
NATHANS, D
果蝇眼中 R8 的发育：神经选择和分化的范例。
DOI：
10.1242/dev.129.6.1295
发表时间：
2002
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Frankfort,BenjaminJ;Mardon,Graeme
通讯作者：
Mardon,Graeme