Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious mononucleosis.
Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious mononucleosis.
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DOI：
10.1039/d2mo00124a
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发表时间：
2022-08-15
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS) 中与能量产生、氨基酸、核苷酸、氮、脂质和神经递质相关的代谢途径可能与 ME/CFS 的病理生理学有关。 4501 名西北大学大学生参与了一项前瞻性纵向研究。我们收集了患病前、传染性单核细胞增多症 (IM) 期间以及 6 个月随访时的数据，其中包括康复者 (N = 18) 与 6 个月后继续发展为 ME/CFS 的患者 (N = 18)。通过检查病前血液样本，我们发现 IM 治疗后注定会发展为严重 ME/CFS 的参与者与恢复的对照组之间存在显着的可检测代谢差异。我们将谷胱甘肽代谢、核苷酸代谢和 TCA 循环（以及其他）确定为潜在的失调途径。病例和对照之间存在差异的途径对于细胞增殖至关重要，特别是在促炎性免疫反应期间。使用留一交叉验证 (LOOCV) 执行一系列二元逻辑回归，我们的模型正确分类了严重 ME/CFS 组并恢复了对照，准确度为 97.2%，敏感性为 94.4%，特异性为 100.0%。这些变化与我们报道的 IM 后 6 个月注定会发展为严重 ME/CFS 的患者促炎细胞因子的升高一致。
Metabolic pathways related to energy production, amino acids, nucleotides, nitrogen, lipids, and neurotransmitters in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may contribute to the pathophysiology of ME/CFS. 4501 Northwestern University college students were enrolled in a prospective, longitudinal study. We collected data before illness, during infectious mononucleosis (IM), and at a 6 month follow-up for those who recovered (N = 18) versus those who went on to develop ME/CFS 6 months later (N = 18). Examining pre-illness blood samples, we found significant detectable metabolite differences between participants fated to develop severe ME/CFS following IM versus recovered controls. We identified glutathione metabolism, nucleotide metabolism, and the TCA cycle (among others) as potentially dysregulated pathways. The pathways that differed between cases and controls are essential for proliferating cells, particularly during a pro-inflammatory immune response. Performing a series of binary logistic regressions using a leave-one-out cross-validation (LOOCV), our models correctly classified the severe ME/CFS group and recovered controls with an accuracy of 97.2%, sensitivity of 94.4%, and specificity of 100.0%. These changes are consistent with the elevations in pro-inflammatory cytokines that we have reported for patients fated to develop severe ME/CFS 6 months after IM.
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影响因子：
11.8
作者：
Jason, Leonard A.;Cotler, Joseph;Katz, Ben Z.
通讯作者：
Katz, Ben Z.
影响因子：
2.6
作者：
Jason LA;Sunnquist M
通讯作者：
Sunnquist M
DOI：
10.29245/2767-5122/2021/1.1129
发表时间：
2022
期刊：
Journal of rehabilitation therapy
影响因子：
--
作者：
Jason LA;Cotler J;Islam MF;Furst J;Katz BZ
通讯作者：
Katz BZ
影响因子：
3.5
作者：
Rider, J. E.;Hacker, A.;Casero, R. A., Jr.
通讯作者：
Casero, R. A., Jr.
影响因子：
10.3
作者：
Moore, Steven C.;Playdon, Mary C.;Ziegler, Regina G.
通讯作者：
Ziegler, Regina G.