Contraceptive use among women with kidney transplants in the United States.

Contraceptive use among women with kidney transplants in the United States.
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DOI:
10.1007/s40620-021-01181-0
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发表时间:
2022-03
影响因子:
3.4
通讯作者:
Verma P
Verma P
中科院分区:
医学3区
文献类型:
--
作者:
Shah S;Christianson AL;Bumb S;Verma P

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肾脏移植可以改善患有终末期肾病的女性的生殖功能。对于有肾移植史的女性的避孕措施知之甚少。我们利用美国肾脏数据系统的数据,对 2005 年 1 月 1 日至 2013 年 12 月 31 日期间接受肾移植的年龄在 15 至 44 岁之间、以医疗保险为主要支付者的女性进行了评估,并链接了来自联合器官共享网络的数据,持续时间为移植日期后长达三年。我们确定了避孕药具的使用率,并使用多变量逻辑回归来确定与避孕药具使用相关的因素。该研究队列包括 13,150 名女性,代表 26,624 人年。避孕药具使用率为9.5%。与 15-24 岁女性相比,30-34 岁(OR 0.67;CI 0.58-0.78)、35-39 岁(OR 0.36;CI 0.31-0.43)和 40-44 岁(OR 0.23;CI 0.19-0.28)女性的避孕药具使用率较低。与白人女性相比,黑人女性(OR 1.26;CI 1.10-1.43)和美洲原住民女性(OR 1.52;CI 1.02-2.26)的避孕药具使用率更高。与移植后第一年相比,女性在移植后第二年(OR 0.87;CI 0.79-0.94)和移植后第三年(OR0.69;CI 0.62-0.76)的避孕措施使用率较低。有糖尿病史的女性使用避孕药具的可能性较低(OR 0.80;CI 0.65-0.99)。在接受肾移植的女性中,避孕药具的使用率仍然很低,仅为 9.5%。与避孕药具使用可能性较高相关的因素包括年龄较小、黑人和美洲原住民种族/民族;以及移植后第二年和第三年。糖尿病史与使用避孕药具的可能性较低有关。该研究强调需要提高肾移植女性安全有效避孕措施的认识。在线版本包含可在 10.1007/s40620-021-01181-0 获取的补充材料。
Kidney transplant improves reproductive function in women with end-stage kidney disease. Little is known about contraceptive use in women with history of kidney transplants. Using data from the United States Renal Data System, we evaluated for each calendar year women with kidney transplantation between 1/1/2005 and 12/31/2013 who were aged 15–44 years with Medicare as the primary payer and linked data from the United Network for Organ Sharing, for up to three entire years after the date of transplantation. We determined rates of contraceptive use and used multivariable logistic regression to identify factors associated with contraceptive use. The study cohort included 13,150 women and represented 26,624 person-years. The rate of contraceptive use was 9.5%. Compared to women aged 15–24 years, contraceptive use was lower in women aged 30–34 years (OR 0.67; CI 0.58–0.78), 35–39 years (OR 0.36; CI 0.31–0.43), and 40–44 years (OR 0.23; CI 0.19–0.28). Compared to white women, contraceptive use was higher both in black women (OR 1.26; CI 1.10–1.43) and Native American women (OR 1.52; CI 1.02–2.26). Women had lower rates of contraceptive use in the second-year post-transplant (OR 0.87; CI 0.79–0.94) and the third-year post-transplant (OR0.69; CI 0.62–0.76) than in the first-year post-transplant. Women with a history of diabetes had a lower likelihood of contraceptive use (OR 0.80; CI 0.65–0.99). Among women with kidney transplants, contraceptive use remains low at 9.5%. Factors associated with a higher likelihood of contraceptive use include younger age and black and Native American race/ethnicity; and second- and third-year post-transplant. The history of diabetes is associated with a lower likelihood of contraceptive use. The study highlights the need of increasing awareness for safe and effective contraceptive use in women with kidney transplants. The online version contains supplementary material available at 10.1007/s40620-021-01181-0.
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