Absorption, metabolism and antioxidative effects of tea catechin in humans.
Absorption, metabolism and antioxidative effects of tea catechin in humans.
复制标题
茶儿茶素在人体中的吸收、代谢和抗氧化作用。
作者：
T. Miyazawa
绿茶在日本和全世界都是一种受欢迎的饮料。在过去的十年中，流行病学研究表明，茶儿茶素的摄入与心血管疾病的风险降低有关。体外生化研究已经报道儿茶素，特别是表没食子儿茶素-3-没食子酸酯（EGCg），有助于防止血浆低密度脂蛋白（LDL）的氧化。低密度脂蛋白氧化被认为是动脉粥样硬化斑块形成和随后心血管疾病的重要步骤。代谢研究表明，EGCg补充剂进入人血浆的最大浓度为4400 pmol/mL。这样的浓度足以在血液中发挥抗氧化活性。茶儿茶素的有效抗氧化特性可能有助于防止LDL氧化。通过测定血浆过氧化磷脂酰胆碱（PCOOH）作为氧化脂蛋白的标志物，研究绿茶儿茶素补充对人体血浆抗氧化能力的影响是有意义的。
Green tea is consumed as a popular beverage in Japan and throughout the world. During the past decade, epidemiological studies have shown that tea catechin intake is associated with lower risk of cardiovascular disease. In vitro biochemical studies have reported that catechins, particularly epigallocatechin-3-gallate (EGCg), help to prevent oxidation of plasma low-density lipoprotein (LDL). LDL oxidation has been recognized to be an important step in the formation of atherosclerotic plaques and subsequent cardiovascular disease. Metabolic studies have shown that EGCg supplement is incorporated into human plasma at a maximum concentration of 4400 pmol/mL. Such concentrations would be enough to exert antioxidative activity in the blood stream. The potent antioxidant property of tea catechin may be beneficial in preventing the oxidation of LDL. It is of interest to examine the effect of green tea catechin supplementation on antioxidant capacity of plasma in humans by measuring plasma phosphatidylcholine hydroperoxide (PCOOH) as a marker of oxidized lipoproteins.
DOI：
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发表时间：
1995-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Mao-jung Lee;Zhi-Yuan Wang;He Li;Laishun Chen;Yang Sun;Steve Gobbo;D. Balentine;Chung S. Yane
通讯作者：
Mao-jung Lee;Zhi-Yuan Wang;He Li;Laishun Chen;Yang Sun;Steve Gobbo;D. Balentine;Chung S. Yane
超越胆固醇。
DOI：
10.1056/nejm198904063201407
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
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作者：
Steinberg,D;Parthasarathy,S;Carew,TE;Khoo,JC;Witztum,JL
通讯作者：
Witztum,JL