Signaling complexes of voltage-gated sodium and calcium channels.
Signaling complexes of voltage-gated sodium and calcium channels.
复制标题
DOI：
10.1016/j.neulet.2010.08.085
复制
发表时间：
2010-12-10
影响因子：
2.5
通讯作者：
Catterall WA
中科院分区：
文献类型：
--
作者：
Catterall WA
由电压门控Na+和Ca 2+通道激活产生的膜去极化和细胞内Ca 2+瞬变是局部信号，其启动生理过程，如动作电位传导、突触传递和兴奋-收缩偶联。将效应蛋白和调节蛋白靶向离子通道是确保响应局部刺激的信号传导事件的速度、特异性和精确调节的重要机制。本文综述了实验结果表明，Na+和Ca 2+通道形成局部信号复合物，其中效应蛋白，锚定蛋白和调节蛋白直接与离子通道相互作用。这些通道的细胞内结构域作为信号平台，介导它们参与细胞内信号传导过程。这些蛋白质-蛋白质相互作用对于通过调节脑神经元中的Na+通道功能来调节细胞可塑性、通过调节突触前CaV 2通道来调节短期突触可塑性以及通过调节骨骼肌和心肌中的突触后CaV 1通道来调节战斗或逃跑反应是重要的。这些局部信号复合物对于电兴奋性、突触传递和兴奋-收缩偶联的正常功能和调节是必不可少的。
Membrane depolarization and intracellular Ca2+ transients generated by activation of voltage-gated Na+ and Ca2+ channels are local signals, which initiate physiological processes such as action potential conduction, synaptic transmission, and excitation-contraction coupling. Targeting of effector proteins and regulatory proteins to ion channels is an important mechanism to ensure speed, specificity, and precise regulation of signaling events in response to local stimuli. This article reviews experimental results showing that Na+ and Ca2+ channels form local signaling complexes, in which effector proteins, anchoring proteins, and regulatory proteins interact directly with ion channels. The intracellular domains of these channels serve as signaling platforms, mediating their participation in intracellular signaling processes. These protein-protein interactions are important for regulation of cellular plasticity through modulation of Na+ channel function in brain neurons, for short-term synaptic plasticity through modulation of presynaptic CaV2 channels, and for the fight-or-flight response through regulation of postsynaptic CaV1 channels in skeletal and cardiac muscle. These localized signaling complexes are essential for normal function and regulation of electrical excitability, synaptic transmission, and excitation-contraction coupling.
登录
查看更多内容
DOI：
10.1073/pnas.82.8.2528
发表时间：
1985-01-01
影响因子：
11.1
作者：
CURTIS, BM;CATTERALL, WA
通讯作者：
CATTERALL, WA
DOI：
10.1073/pnas.88.23.10778
发表时间：
1991-12-01
影响因子：
11.1
作者：
DEJONGH, KS;WARNER, C;CATTERALL, WA
通讯作者：
CATTERALL, WA
影响因子：
5.5
作者：
Borst, JGG;Sakmann, B
通讯作者：
Sakmann, B
影响因子：
5.3
作者：
Ahn, Misol;Beacham, Daniel;Catterall, William A.
通讯作者：
Catterall, William A.
影响因子：
64.8
作者：
BEAN, BP
通讯作者：
BEAN, BP