Evolution: Tracing the origins of centrioles, cilia, and flagella.

Evolution: Tracing the origins of centrioles, cilia, and flagella.
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DOI:
10.1083/jcb.201011152
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发表时间:
2011-07-25
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Bettencourt-Dias M
Bettencourt-Dias M
中科院分区:
其他
文献类型:
--
作者:
Carvalho-Santos Z;Azimzadeh J;Pereira-Leal JB;Bettencourt-Dias M

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中心粒/基体(CBBs)是基于微管的圆柱形细胞器,其使中心体、纤毛和鞭毛的形成成核。CBB、纤毛和鞭毛是祖先的结构;它们存在于所有主要的真核生物群中。尽管它们的核心结构保持不变,但它们的结构、功能和生物起源存在变异性。最近的基因组和功能研究提供了深入了解这些细胞器的结构和功能的演变。
Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral structures; they are present in all major eukaryotic groups. Despite the conservation of their core structure, there is variability in their architecture, function, and biogenesis. Recent genomic and functional studies have provided insight into the evolution of the structure and function of these organelles.
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