The effects of hemodynamic force on embryonic development.-猫眼课题宝

DOI：

10.1111/j.1549-8719.2010.00025.x

发表时间：

2010-04

期刊：

Microcirculation (New York, N.Y. : 1994)

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Culver JC;Dickinson ME

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927969/?report=classic

血管对血液动力学力的反应早已为人们所知，并且已经确定了几种机械转导途径。然而，直到最近，我们才开始了解血液动力学对胚胎发育的影响。在这篇综述中，我们将讨论具体的例子，说明血液动力学的作用，在胚胎的发展过程中，特别注重血管系统的发展和心脏的形态发生。我们还将讨论在胎盘形成过程中，以及在调节胚胎、造血、神经和间充质干细胞的维持和分裂中，机械传导和血液动力学的重要功能。在妊娠和胚胎发育期间机械敏感性通路的病理性失调可能导致心血管出生缺陷的发生，以及各种其他疾病，包括先兆子痫。因此，有必要为未来的研究重点更好地了解血液动力学力在胚胎发育过程中的生理效应及其在疾病的发病机制中的作用。

Blood vessels have long been known to respond to hemodynamic force, and several mechanotransduction pathways have been identified. However, only recently have we begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis of the heart. We will also discuss the important functions served by mechanotransduction and hemodynamic force during placentation, as well as in regulating the maintenance and division of embryonic, hematopoietic, neural, and mesenchymal stem cells. Pathological misregulation of mechanosensitive pathways during pregnancy and embryonic development may contribute to the occurrence of cardiovascular birth defects, as well as to a variety of other diseases, including preeclampsia. Thus, there is a need for future studies focusing on better understanding the physiological effects of hemodynamic force during embryonic development and their role in the pathogenesis of disease.