Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review.
Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review.
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DOI：
10.3389/fcell.2021.745394
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发表时间：
2021
影响因子：
5.5
通讯作者：
Rezazadeh M
中科院分区：
文献类型：
--
作者：
Asadi MR;Rahmanpour D;Moslehian MS;Sabaie H;Hassani M;Ghafouri-Fard S;Taheri M;Rezazadeh M
应激颗粒（SGs）的组装是一种众所周知的细胞策略，可以减少应激相关的损伤，促进细胞存活。除了在应激反应中发挥基本作用外，SGs已成为人类健康的重要参与者。SGs在癌细胞形成、进展和转移中的关键作用是有意义的。近年来，研究人员发现一些SG成分通过肿瘤相关信号通路和其他机制在肿瘤发生和癌症转移中发挥作用。基因本体分析揭示了这些蛋白组分在SGs结构中的作用。参与翻译过程，调控mRNA的稳定性，并在细胞质和细胞核中发挥作用是SG蛋白的主要特征。目前的范围综述旨在考虑所有关于SGs对癌症形成、增殖和转移影响的研究，并基于六阶段方法结构和PRISMA指南进行。在2021年7月之前，系统检索了7个数据库中符合条件的文章。对出版物进行筛选，并对提取的数据进行定量和定性分析。对71个SGs蛋白组分进行Go分析。值得注意的是，在研究中考虑的蛋白质中，G3BP1、TIA1、TIAR和YB1所占比例最大。总之，这篇综述试图通过回顾所有的研究来证明和提供一个全面的总结SGs在癌症的形成、进展和转移中的作用。
The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-related damage and promoting cell survival. SGs have become important players in human health, in addition to their fundamental role in the stress response. The critical role of SGs in cancer cells in formation, progression, and metastasis makes sense. Recent researchers have found that several SG components play a role in tumorigenesis and cancer metastasis via tumor-associated signaling pathways and other mechanisms. Gene-ontology analysis revealed the role of these protein components in the structure of SGs. Involvement in the translation process, regulation of mRNA stability, and action in both the cytoplasm and nucleus are among the main features of SG proteins. The present scoping review aimed to consider all studies on the effect of SGs on cancer formation, proliferation, and metastasis and performed based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted before July 2021. Publications were screened, and quantitative and qualitative analysis was performed on the extracted data. Go analysis was performed on seventy-one SGs protein components. Remarkably G3BP1, TIA1, TIAR, and YB1 have the largest share among the proteins considered in the studies. Altogether, this scoping review tries to demonstrate and provide a comprehensive summary of the role of SGs in the formation, progression, and metastasis of cancer by reviewing all studies.
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影响因子：
--
作者：
Andersson MK;Ståhlberg A;Arvidsson Y;Olofsson A;Semb H;Stenman G;Nilsson O;Aman P
通讯作者：
Aman P
DOI：
10.1016/j.bbadis.2018.02.017
发表时间：
2018-05-01
影响因子：
6.2
作者：
Chen, Hsiao-Yun;Lin, Liang-Ting;Chen, Ming-Teh
通讯作者：
Chen, Ming-Teh
DOI：
10.1083/jcb.106.4.1131
发表时间：
1988-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Collier NC;Heuser J;Levy MA;Schlesinger MJ
通讯作者：
Schlesinger MJ
影响因子：
11.2
作者：
Bartkowiak, Kai;Kwiatkowski, Marcel;Pantel, Klaus
通讯作者：
Pantel, Klaus
DOI：
10.1016/j.jbc.2021.100296
发表时间：
2021-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brown NP;Vergara AM;Whelan AB;Guerra P;Bolger TA
通讯作者：
Bolger TA