A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients.
A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients.
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DOI：
10.1038/s41598-022-27202-x
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发表时间：
2023-01-02
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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弥漫性轴索损伤（DAI）是外伤性脑损伤的一种亚型，可引起急性期意识障碍和广泛的慢性脑萎缩。考虑到脑干损伤在DAI中的重要性，需要一种有效的评估脑干体积的方法。我们通过分析t1加权磁共振图像获得182名健康成人的体积测量值，并创建了一个基于年龄/性别/颅内体积的定量模型来估计脑干和大脑的正常健康体积。然后，我们将该模型应用于22名DAI患者的体积测量，其中大多数患者处于长期慢性期，没有明显的局灶性损伤，以估计不同脑区域的体积与预期正常健康体积的百分比差异，并研究其与创伤后失忆症持续时间的关系（这是损伤严重程度的早期标志）。全脑干平均损失13.9%。此外，整个脑干，特别是脑桥和中脑的损失百分比与创伤后失忆症的持续时间呈显著负相关。我们的研究结果表明，损伤严重程度，如创伤后健忘症持续时间，是影响DAI患者慢性期脑干体积的因素之一。
Diffuse axonal injury (DAI) is a subtype of traumatic brain injury that causes acute-phase consciousness disorders and widespread chronic-phase brain atrophy. Considering the importance of brainstem damage in DAI, a valid method for evaluating brainstem volume is required. We obtained volume measurements from 182 healthy adults by analyzing T1-weighted magnetic resonance images, and created an age-/sex-/intracranial volume-based quantitative model to estimate the normal healthy volume of the brainstem and cerebrum. We then applied this model to the volume measurements of 22 DAI patients, most of whom were in the long-term chronic phase and had no gross focal injury, to estimate the percentage difference in volume from the expected normal healthy volume in different brain regions, and investigated its association with the duration of posttraumatic amnesia (which is an early marker of injury severity). The average loss of the whole brainstem was 13.9%. Moreover, the percentage loss of the whole brainstem, and particularly of the pons and midbrain, was significantly negatively correlated with the duration of posttraumatic amnesia. Our findings suggest that injury severity, as denoted by the duration of posttraumatic amnesia, is among the factors affecting the chronic-phase brainstem volume in patients with DAI.
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影响因子：
5.7
作者：
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通讯作者：
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DOI：
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Alzheimer's Disease Neuroimaging Initiative