Faecal Microbiota Composition Varies between Patients with Breast Cancer and Healthy Women: A Comparative Case-Control Study.
Faecal Microbiota Composition Varies between Patients with Breast Cancer and Healthy Women: A Comparative Case-Control Study.
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DOI：
10.3390/nu13082705
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发表时间：
2021-08-05
期刊：
影响因子：
5.9
通讯作者：
Bard JM
中科院分区：
文献类型：
--
作者：
Bobin-Dubigeon C;Luu HT;Leuillet S;Lavergne SN;Carton T;Le Vacon F;Michel C;Nazih H;Bard JM
肠道微生物群在许多疾病中起着至关重要的作用，如肥胖、肠易激病（IBD）和癌症。本研究旨在描述早期乳腺癌（BC）患者和健康对照者的粪便微生物群。收集新诊断的乳腺癌患者的粪便，主要是没有特定类型（HR+和HER2−）的浸润性癌，在任何治疗前和健康对照进行元条形码分析。我们发现，作为多样性指数的香农指数在BC组中与对照组相比在统计学上较低。这项工作强调了与健康女性相比，早期BC患者的微生物多样性减少，厚壁菌门相对丰富，拟杆菌门减少。观察到臭杆菌、丁酸单胞菌和粪球菌的相对丰度呈下降趋势。这项初步研究表明，乳腺癌患者的肠道细菌组成可能与健康受试者不同。
The intestinal microbiota plays an essential role in many diseases, such as obesity, irritable bowel disease (IBD), and cancer. This study aimed to characterize the faecal microbiota from early-stage breast cancer (BC) patients and healthy controls. Faeces from newly diagnosed breast cancer patients, mainly for an invasive carcinoma of no specific type (HR+ and HER2−), before any therapeutic treatment and healthy controls were collected for metabarcoding analyses. We show that the Shannon index, used as an index of diversity, was statistically lower in the BC group compared to that of controls. This work highlights a reduction of microbial diversity, a relative enrichment in Firmicutes, as well as a depletion in Bacteroidetes in patients diagnosed with early BC compared to those of healthy women. A tendency towards a decreased relative abundance of Odoribacter sp., Butyricimonas sp., and Coprococcus sp. was observed. This preliminary study suggests that breast cancer patients may differ from healthy subjects in their intestinal bacterial composition.
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
4.6
作者：
Ling Z;Jin C;Xie T;Cheng Y;Li L;Wu N
通讯作者：
Wu N
DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.3390/ijerph15081747
发表时间：
2018-08-14
影响因子：
--
作者：
Fernández MF;Reina-Pérez I;Astorga JM;Rodríguez-Carrillo A;Plaza-Díaz J;Fontana L
通讯作者：
Fontana L
影响因子：
12.3
作者：
Montassier E;Al-Ghalith GA;Ward T;Corvec S;Gastinne T;Potel G;Moreau P;de la Cochetiere MF;Batard E;Knights D
通讯作者：
Knights D