The role of the microbiome in cancer development and therapy.
The role of the microbiome in cancer development and therapy.
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DOI：
10.3322/caac.21398
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发表时间：
2017-07-08
期刊：
影响因子：
--
通讯作者：
Bultman SJ
中科院分区：
文献类型：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
人体拥有增强的微生物群，部分地通过其巨大的代谢能力及其对免疫菌株功能的深刻影响。基于元基因组测序的微生物组研究，相结合微生物群的组成改变了无法区分微生物群的变化是癌症的原因或影响，通过使用一种或多种特异性细菌殖民的Gnotobiotic小鼠模型进行严格控制的临床前研究支持了关键作用。诸如调节注射，诱导DNA损伤以及产生参与肿瘤发生或抑制肿瘤的代谢物等机制。有证据表明，可以通过将益生菌作为检查点免疫疗法的调节器或设计针对微生物酶的小分子来操纵菌群，以改善癌症治疗。
The human body harbors an enormous number of microbiota that influence cancer susceptibility, in part, via their prodigious metabolic capacity and their profound influence on immune cell function. Microbial pathogens drive tumorigenesis in 15–20% of cancer cases. An even larger number of malignancies are associated with an altered composition of commensal microbiota (dysbiosis) based on microbiome studies utilizing metagenomic sequencing. Although association studies cannot distinguish whether changes in microbiota are causes or effects of cancer, a causative role is supported by rigorously controlled pre-clinical studies utilizing gnotobiotic mouse models colonized with one or more specific bacteria. These studies demonstrate that microbiota can alter cancer susceptibility and progression by diverse mechanisms such as modulating inflammation, inducing DNA damage, and producing metabolites involved in oncogenesis or tumor suppression. Evidence is emerging that microbiota can be manipulated for improving cancer treatment. By incorporating probiotics as adjuvants for checkpoint immunotherapy or by designing small molecules that target microbial enzymes, microbiota can be harnessed to improve cancer care.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
4.6
作者：
Chan AA;Bashir M;Rivas MN;Duvall K;Sieling PA;Pieber TR;Vaishampayan PA;Love SM;Lee DJ
通讯作者：
Lee DJ
影响因子：
64.8
作者：
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Bork, Peer
影响因子：
12.2
作者：
Araujo-Perez, Felix;McCoy, Amber N.;Keku, Temitope O.
通讯作者：
Keku, Temitope O.
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.