Oral bisphosphonate use and lung cancer incidence among postmenopausal women.
Oral bisphosphonate use and lung cancer incidence among postmenopausal women.
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DOI：
10.1093/annonc/mdy097
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发表时间：
2018-06-01
期刊：
影响因子：
--
通讯作者：
Wactawski-Wende J
中科院分区：
文献类型：
--
作者：
Tao MH;Chen S;Freudenheim JL;Cauley JA;Johnson KC;Mai X;Sarto GE;Wakelee H;Boffetta P;Wactawski-Wende J
双膦酸盐是治疗老年人群骨质疏松症的常用药物。包括妇女健康倡议(WHI)在内的几项研究发现，双膦酸盐的使用与乳腺癌和子宫内膜癌的风险呈负相关，但对其与其他常见恶性肿瘤的相关性知之甚少。这项研究的目的是评估使用双膦酸盐与WHI中肺癌发病率的相关性。1993年至1998年，对151名参加WHI的绝经后妇女进行了口服双膦酸类药物的使用与肺癌风险之间的相关性研究。 432名妇女均为绝经后妇女。在基线和随访期间，参与者完成了包括双磷酸盐在内的常用药物的清单。在平均随访13.3年 年后，2,511名妇女被诊断为偶发肺癌。口服双磷酸盐使用者和从不使用双膦酸盐使用者之间的肺癌发病率没有差异(调整后的危险比 = 为0.91；95%可信区间为0.80-1.04；P = 为0.16)。然而，在那些从不吸烟的人中观察到了相反的关联(危险比 = 为0.57，95%可信区间为0.39-0.84；P <； 为0.01)。在这一庞大的绝经后女性前瞻性队列中，口服双膦酸盐与从不吸烟的人患肺癌的风险显著降低相关，这表明双膦酸盐可能对肺癌具有保护作用。还需要更多的研究来证实我们的发现。
Bisphosphonates are common medications for the treatment of osteoporosis in older populations. Several studies, including the Women’s Health Initiative (WHI), have found inverse associations of bisphosphonate use with risk of breast and endometrial cancer, but little is known about its association with other common malignancies. The objective of this study was to evaluate the association of bisphosphonate use on the incidence of lung cancer in the WHI. The association between oral bisphosphonate use and lung cancer risk was examined in 151 432 postmenopausal women enrolled into the WHI in 1993–1998. At baseline and during follow-up, participants completed an inventory of regularly used medications including bisphosphonates. After a mean follow-up of 13.3 years, 2511 women were diagnosed with incident lung cancer. There was no evidence of a difference in lung cancer incidence between oral bisphosphonate users and never users (adjusted hazard ratio = 0.91; 95% confidence intervals, 0.80–1.04; P = 0.16). However, an inverse association was observed among those who were never smokers (hazard ratio = 0.57, 95% confidence interval, 0.39–0.84; P < 0.01). In this large prospective cohort of postmenopausal women, oral bisphosphonate use was associated with significantly lower lung cancer risk among never smokers, suggesting bisphosphonates may have a protective effect against lung cancer. Additional studies are needed to confirm our findings.
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影响因子：
45.3
作者：
Newcomb, Polly A.;Passarelli, Michael N.;Chlebowski, Rowan T.
通讯作者：
Chlebowski, Rowan T.
影响因子：
4
作者：
Cairoli, E.;Eller-Vainicher, C.;Chiodini, I.
通讯作者：
Chiodini, I.
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
4.6
作者：
Meraviglia, S.;Eberl, M.;Hayday, A. C.
通讯作者：
Hayday, A. C.
DOI：
10.2165/00024677-200605060-00006
发表时间：
2006-01-01
期刊：
Treatments in endocrinology
影响因子：
--
作者：
Boonen, Steven;Bouillon, Roger;Vanderschueren, Dirk
通讯作者：
Vanderschueren, Dirk