Astrocyte heterogeneity in the brain: from development to disease.

Astrocyte heterogeneity in the brain: from development to disease.
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DOI:
10.3389/fncel.2015.00076
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发表时间:
2015
影响因子:
5.3
通讯作者:
Hedin-Pereira C
Hedin-Pereira C
中科院分区:
医学2区
文献类型:
--
作者:
Schitine C;Nogaroli L;Costa MR;Hedin-Pereira C

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在过去的几十年里,星形胶质细胞已经从神经元活动的被动支持者上升为大脑功能和认知的核心参与者。同样地,星形胶质细胞的异质性开始被认识到,与以前预测的同质群体相反。在这篇综述中,我们专注于星形胶质细胞的异质性在其形态,蛋白质表达和功能方面,并在历史的角度辩论的多样性,在胶质祖细胞,以及他们如何可能反映成熟的星形胶质细胞的异质性。我们讨论的数据表明,不同的祖细胞可能有未知的作用,在发育过程中。我们已经接近的功能星形胶质细胞亚群的精神和神经系统疾病的发病。
In the last decades, astrocytes have risen from passive supporters of neuronal activity to central players in brain function and cognition. Likewise, the heterogeneity of astrocytes starts to become recognized in contrast to the homogeneous population previously predicted. In this review, we focused on astrocyte heterogeneity in terms of their morphological, protein expression and functional aspects, and debate in a historical perspective the diversity encountered in glial progenitors and how they may reflect mature astrocyte heterogeneity. We discussed data that show that different progenitors may have unsuspected roles in developmental processes. We have approached the functions of astrocyte subpopulations on the onset of psychiatric and neurological diseases.
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