Light-intensity and moderate-to-vigorous intensity physical activity among older adult breast cancer survivors with obesity: A narrative review.
Light-intensity and moderate-to-vigorous intensity physical activity among older adult breast cancer survivors with obesity: A narrative review.
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DOI：
10.1002/cam4.4841
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发表时间：
2022-12
期刊：
影响因子：
4
通讯作者：
Schmitz, Kathryn H.
中科院分区：
文献类型：
--
作者：
Gordon, Brett R.;Caru, Maxime;Blair, Cindy K.;Bluethmann, Shirley M.;Conroy, David E.;Doerksen, Shawna E.;Hakun, Jonathon G.;Sturgeon, Kathleen M.;Potiaumpai, Melanie;Sciamanna, Christopher N.;Schmitz, Kathryn H.
随着人口老龄化、乳腺癌发病率上升、生存率提高以及肥胖流行，患有肥胖症的老年乳腺癌幸存者人数将会不断增加。这个复杂的人群往往患有多种疾病，面临着多种不良健康结果的风险，包括复发、心血管疾病、痴呆和糖尿病，以及许多有害症状，包括炎症恶化、乳腺癌相关淋巴水肿、行动障碍、认知障碍、焦虑和抑郁症状。大量荟萃分析和随机对照试验证据表明，遵守世界卫生组织和 2018 年美国体力活动指南的中度至剧烈体力活动 (MVPA) 水平可降低全因死亡风险，并改善症状。然而，很少有幸存者达到推荐水平的 MVPA，并且与其多病相关的症状可能妨碍他们达到足够水平的 MVPA。有必要对这一人群进行 MVPA 的进一步研究；然而，对于面临满足 MVPA 建议的广泛挑战的复杂人群来说，未充分研究的轻强度体力活动 (LIPA) 可能是比 MVPA 更务实的目标。增加这些幸存者的总活动量可能会带来巨大的好处，而 LIPA 处方可能是比 MVPA 更务实的方法来帮助实现这一转变。我们对 MVPA 和 LIPA 在该人群中的证据进行了广泛的叙述性回顾，涉及转化科学领域（临床、实施和公共卫生）的一系列健康结果，并确定了未来研究的一些方向，重点是了解 LIPA 潜在的多种健康影响。额外的 LIPA 研究是必要的，因为 LIPA 处方可能是有效促进这一复杂人群身体活动的务实策略。
With an aging population, rising incidence of breast cancer, improved survival rates, and obesity epidemic, there will be a growing population of older adult breast cancer survivors with obesity. This complex population, often with multimorbidity, is at risk for several poor health outcomes, including recurrence, cardiovascular disease, dementia, and diabetes, and a number of deleterious symptoms, including a worsened inflammatory profile, breast cancer‐ related lymphedema, mobility disability, cognitive impairment, anxiety, and depressive symptoms. A wealth of meta‐analytic and randomized controlled trial evidence show that adherence to World Health Organization and 2018 United States Physical Activity guidelines‐based levels of moderate‐to‐vigorous physical activity (MVPA) reduces risk of all‐cause mortality, and improves symptoms. However, few survivors engage in recommended levels of MVPA, and symptoms related to their multimorbidity may preclude engaging in sufficient levels of MVPA. Additional research of MVPA in this population is warranted; however, understudied light‐intensity physical activity (LIPA) may be a more pragmatic target than MVPA among this complex population facing extensive challenges meeting MVPA recommendations. Large benefits are likely to occur from increasing these survivors' total activity, and LIPA prescriptions may be a more pragmatic approach than MVPA to aid this transition. We present a broad, narrative review of the evidence for MVPA and LIPA in this population on an array of health outcomes across the translational science spectrum (clinical, implementation, and public health), and identify a number of directions for future research focused on understanding the potential diverse health effects of LIPA. Additional LIPA research is warranted, as LIPA prescriptions may be a pragmatic strategy to effectively promote physical activity to this complex population.
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DOI：
10.1016/j.mcna.2011.11.003
发表时间：
2012-01
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Dhingra R;Vasan RS
通讯作者：
Vasan RS
影响因子：
4.1
作者：
Fishman EI;Steeves JA;Zipunnikov V;Koster A;Berrigan D;Harris TA;Murphy R
通讯作者：
Murphy R
影响因子：
28.4
作者：
Cao, Chao;Friedenreich, Christine M.;Yang, Lin
通讯作者：
Yang, Lin
影响因子：
13.8
作者：
Du, Yang;Liu, Buyun;Bao, Wei
通讯作者：
Bao, Wei
影响因子：
1.5
作者：
Bluethmann, Shirley M.;Foo, Wayne;Schmitz, Kathryn H.
通讯作者：
Schmitz, Kathryn H.