Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia.
Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia.
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DOI：
10.2337/dc11-2114
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发表时间：
2012-06
期刊：
影响因子：
16.2
通讯作者：
Rao AK
中科院分区：
文献类型：
--
作者：
Singh A;Boden G;Homko C;Gunawardana J;Rao AK
测定1型糖尿病患者组织因子促凝活性（TF-PCA），探讨高血糖及高血糖合并高胰岛素血症对TF-PCA的影响。我们已经确定了循环TF-PCA和其他凝血因子的基础（高血糖）条件下，急性纠正高血糖后，在24小时的选择性高血糖，并在24小时的高血糖加高胰岛素血症在9型1糖尿病患者和7个非糖尿病对照组。如先前在2型糖尿病患者中所示，1型糖尿病患者的基础TF-PCA和血浆凝血因子VIIa（FVIIa）高于非糖尿病对照受试者。然而，与2型糖尿病相比，正常化葡萄糖并没有降低升高的TF-PCA水平，并且提高葡萄糖或葡萄糖加胰岛素水平并没有增加TF-PCA。1型糖尿病患者的循环TF-PCA和FVIIa水平升高，并处于促凝血状态，可能使他们易患急性心血管事件。1型和2型糖尿病患者TF-PCA的调节机制不同，需要进一步探讨。
To determine tissue factor procoagulant activity (TF-PCA) in patients with type 1 diabetes and to examine effects of hyperglycemia and hyperglycemia plus hyperinsulinemia on TF-PCA. We have determined circulating TF-PCA and other coagulation factors under basal (hyperglycemic) conditions, after acute correction of hyperglycemia, in response to 24 h of selective hyperglycemia, and in response to 24 h of hyperglycemia plus hyperinsulinemia in nine type 1 diabetic patients and in seven nondiabetic control subjects. As shown previously in patients with type 2 diabetes, basal TF-PCA and plasma coagulation factor VIIa (FVIIa) were higher in patients with type 1 diabetes than in nondiabetic control subjects. However, in contrast with type 2 diabetes, normalizing glucose did not decrease the elevated TF-PCA levels, and raising glucose or glucose plus insulin levels did not increase TF-PCA. Patients with type 1 diabetes have elevated circulating TF-PCA and FVIIa levels and are in a procoagulant state that may predispose them to acute cardiovascular events. The mechanisms regulating TF-PCA in patients with type 1 and type 2 diabetes are different and should be further explored.
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作者：
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DOI：
10.1161/01.atv.0000199519.37089.a0
发表时间：
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