Abscisic acid negatively regulates the Polycomb-mediated H3K27me3 through the PHD-finger protein, VIL1.

Abscisic acid negatively regulates the Polycomb-mediated H3K27me3 through the PHD-finger protein, VIL1.
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脱落酸通过PhD-Finger蛋白VIL1负性调节Polycomb介导的H3K27me3。

DOI:
10.1111/nph.18156
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发表时间:
2022-08
期刊:
影响因子:
9.4
通讯作者:
Sung, Sibum
Sung, Sibum
中科院分区:
生物学1区
文献类型:
--
作者:
Zong, Wei;Kim, Junghyun;Bordiya, Yogendra;Qiao, Hong;Sung, Sibum

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多梳决定了包括开花植物在内的高等真核生物的发育程序。植物激素脱落酸(ABA)在种子和幼苗发育中起着关键作用,并介导对多种环境胁迫的反应,如盐度和干旱。在本研究中,我们发现ABA通过VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5)影响拟南芥多梳抑制复合体2 (PRC2)介导的组蛋白H3 Lys 27三甲基化(H3K27me3),以微调ABSCISIC ACID INSENSITIVE 3 (ABI3)和ABSCISIC ACID INSENSITIVE 4 (ABI4)的及时抑制。vil1突变体在种子萌发早期表现出对ABA的敏感性,并表现出更强的耐旱性。我们的研究表明,ABA信号通路利用染色质重塑复合体的兼性成分来划分ABA应答基因的表达水平。
Polycomb dictates developmental programs in higher eukaryotes, including flowering plants. A phytohormone, Abscisic acid (ABA), plays a pivotal role in seed and seedling development and mediates responses to multiple environmental stresses, such as salinity and drought. In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana. vil1 mutants exhibit hypersensitivity to ABA during early seed germination and show enhanced drought tolerance. Our study revealed that the ABA signaling pathway utilizes a facultative component of the chromatin remodeling complex to demarcate the level of expression of ABA-responsive genes.
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发表时间: 2012-10-30
期刊: eLife
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