Axin1: A novel scaffold protein joins the antiviral network of interferon.
Axin1: A novel scaffold protein joins the antiviral network of interferon.
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Axin1：一种新的支架蛋白加入干扰素的抗病毒网络。
DOI：
10.1111/mmi.14995
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发表时间：
2022-12
影响因子：
3.6
通讯作者：
Liu, Lin
中科院分区：
文献类型：
--
作者：
Guo, Yujie;Bamunuarachchi, Gayan;Vaddadi, Kishore;Zhu, Zhengyu;Gandikota, Chaitanya;Ahmed, Kainat;Pushparaj, Samuel;More, Sunil;Xiao, Xiao;Yang, Xiaoyun;Liang, Yurong;Mukherjee, Sanjay;Baviskar, Pradyumna;Huang, Chaoqun;Li, Shitao;Oomens, Antonius G. P.;Metcalf, Jordan Patrick;Liu, Lin
由流感病毒引起的急性呼吸道感染是一个持续和普遍的公共卫生问题。由I型干扰素（IFN）启动的抗病毒先天免疫是病原体入侵的第一反应者，并提供第一道防线。我们发现Axin 1是一种支架蛋白，在流感病毒感染期间减少。我们还发现Axin 1和Axin 1的化学稳定剂XAV 939的过表达减少了流感病毒在肺上皮细胞中的复制。在呼吸道合胞病毒和水泡性口炎病毒中也观察到这种效应。Axin 1增强I型IFN对流感病毒感染的应答，并激活JNK/c-Jun和Smad 3信号转导。XAV 939保护小鼠免受流感病毒感染。因此，我们的研究为I型IFN应答的调节提供了新的机制见解，并提出了一种新的潜在的靶向Axin 1对抗流感病毒感染的治疗方法。在这项研究中，我们发现宿主蛋白Axin 1可以增强宿主对流感病毒感染的免疫力。这一发现为靶向Axin 1抗流感病毒感染提供了一种新的潜在治疗方法。
Acute respiratory infection by influenza virus is a persistent and pervasive public health problem. Antiviral innate immunity initiated by type I interferon (IFN) is the first responder to pathogen invasion and provides the first line of defense. We discovered that Axin1, a scaffold protein, was reduced during influenza virus infection. We also found that overexpression of Axin1 and the chemical stabilizer of Axin1, XAV939, reduced influenza virus replication in lung epithelial cells. This effect was also observed with respiratory syncytial virus and vesicular stomatitis virus. Axin1 boosted type I IFN response to influenza virus infection and activated JNK/c-Jun and Smad3 signaling. XAV939 protected mice from influenza virus infection. Thus, our studies provide new mechanistic insights into the regulation of the type I IFN response and present a new potential therapeutic of targeting Axin1 against influenza virus infection. In this study, we have discovered that the host protein Axin1 boosts host immunity in response to influenza virus infection. The finding presents a new potential therapeutic of targeting Axin1 against influenza virus infection.
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DOI：
10.1073/pnas.251194298
发表时间：
2001-11-20
影响因子：
11.1
作者：
Bennett, BL;Sasaki, DT;Anderson, DW
通讯作者：
Anderson, DW
影响因子：
88.1
作者：
Medina, Rafael A.;Garcia-Sastre, Adolfo
通讯作者：
Garcia-Sastre, Adolfo
影响因子：
5.4
作者：
Mitra, Ruchira;Baviskar, Pradyumna;Oomens, Antonius G. P.
通讯作者：
Oomens, Antonius G. P.
影响因子：
3.6
作者：
Jinnin, M;Ihn, H;Tamaki, K
通讯作者：
Tamaki, K
影响因子：
5.4
作者：
Li, Zhuan;Yamauchi, Yohei;Nishiyama, Yukihiro
通讯作者：
Nishiyama, Yukihiro