Influenza A viruses: new research developments.

Influenza A viruses: new research developments.
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DOI:
10.1038/nrmicro2613
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发表时间:
2011-07-11
影响因子:
88.1
通讯作者:
Garcia-Sastre, Adolfo
Garcia-Sastre, Adolfo
中科院分区:
生物学1区
文献类型:
--
作者:
Medina, Rafael A.;Garcia-Sastre, Adolfo

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甲型流感病毒是人畜共患病原体,在多种动物宿主(包括鸟类、猪、马和人类)中不断传播和变化。出现能够引起人类流行病或大流行的新型病毒株的可能性很大。在这里,我们讨论了自然发生的流感病毒的监测和表征的价值,并回顾了实验室的新发展对我们了解病毒的宿主向性和毒力的影响。我们还修订了从过去 100 年的大流行病毒中吸取的教训。
Influenza A viruses are zoonotic pathogens that continuously circulate and change in several animal hosts, including birds, pigs, horses and humans. The emergence of novel virus strains that are capable of causing human epidemics or pandemics is a serious possibility. Here, we discuss the value of surveillance and characterization of naturally occurring influenza viruses, and review the impact that new developments in the laboratory have had on our understanding of the host tropism and virulence of viruses. We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years.
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