Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.
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DOI：
10.1111/j.1369-1600.2010.00226.x
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发表时间：
2011-01
影响因子：
3.4
通讯作者：
Koob GF
中科院分区：
文献类型：
--
作者：
Walker BM;Zorrilla EP;Koob GF
Altered dynorphin opioid peptide systems contribute to increased ethanol self-administration during withdrawal following chronic alcohol exposure. We previously identified that the κ-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), selectively reduced ethanol self-administration in dependent animals. The purpose of this study was two-fold: 1) determine whether peripherally-administered nor-BNI could reduce dependence-induced ethanol self-administration and 2) confirm the selective κ-opioid effects of nor-BNI by administering it 24-hrs prior to ethanol self-administration sessions occurring during acute withdrawal. Nor-BNI decreased ethanol self-administration in ethanol-dependent animals, with no effect in nondependent animals. Thus, the κ-opioid/dynorphin system is a viable pharmacotherapeutic target for the treatment of alcoholism.
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影响因子：
2.3
作者：
Lindholm, S;Ploj, K;Nylander, I
通讯作者：
Nylander, I
影响因子：
7.6
作者：
Walker, Brendan M.;Koob, George F.
通讯作者：
Koob, George F.
影响因子：
3.4
作者：
BROADBEAR, JH;NEGUS, SS;WOODS, JH
通讯作者：
WOODS, JH
影响因子：
5.3
作者：
Land, Benjamin B.;Bruchas, Michael R.;Chavkin, Charles
通讯作者：
Chavkin, Charles
影响因子：
3.4
作者：
Todtenkopf, MS;Marcus, JF;Carlezon, WA
通讯作者：
Carlezon, WA