Super-resolution Ultrasound Imaging.
Super-resolution Ultrasound Imaging.
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DOI：
10.1016/j.ultrasmedbio.2019.11.013
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发表时间：
2020-04
影响因子：
2.9
通讯作者：
van Sloun RJG
中科院分区：
文献类型：
--
作者：
Christensen-Jeffries K;Couture O;Dayton PA;Eldar YC;Hynynen K;Kiessling F;O'Reilly M;Pinton GF;Schmitz G;Tang MX;Tanter M;van Sloun RJG
大部分氧气和营养物质的交换都是在小于100微米的血管周围进行的，这使得细胞能够在体内的任何地方茁壮成长。诸如癌症、糖尿病或动脉硬化之类的病理可以深刻地改变微血管系统。不幸的是，医学成像模式只能提供这种规模的间接观察。受光学显微镜的启发，超声定位显微镜绕过了超声成像中穿透和分辨率之间的经典折衷。通过定位单个注射的微泡并以亚波长分辨率跟踪它们的位移，可以在微米尺度上产生血管和速度图。超声超分辨率也已经通过使用相同类型的造影剂的信号波动或通过打开和关闭纳米尺寸的相变造影剂来执行。这些技术目前正在临床前和临床上应用于脑、肾、皮肤、肿瘤和淋巴结的微血管成像。
The majority of exchanges of oxygen and nutrients are performed around vessels smaller than 100 um, allowing cells to thrive everywhere in the body. Pathologies such as cancer, diabetes or arteriosclerosis can profoundly alter the microvasculature. Unfortunately, medical imaging modalities only provide indirect observation at this scale. Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classical compromise between penetration and resolution in ultrasonic imaging. By localizing individual injected microbubbles and tracking their displacement with a subwavelength resolution, vascular and velocity maps can be produced at the scale of the micrometer. Ultrasound super-resolution has also been performed through signal fluctuations with the same type of contrast agents, or through switching on and off nano-sized phase change contrast agents. These techniques are now being applied pre-clinically and clinically for the imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes.
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DOI：
10.1007/s00259-010-1537-7
发表时间：
2010-08-01
影响因子：
9.1
作者：
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影响因子：
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10.6
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影响因子：
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