Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis.
Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis.
复制标题
DOI：
10.1186/bcr1368
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Sternlicht MD
中科院分区：
文献类型：
--
作者：
Sternlicht MD
乳腺产生和输送足量乳汁的部分功能是通过从一个初级上皮芽形成一个广泛的树状分支导管网络。这个过程被称为分支形态发生，开始于胎儿发育，出生后暂停，在青春期对雌激素的反应中恢复，在乳房脂肪垫边缘被满足后，在卵巢循环刺激的反应中得到完善。因此，它是由系统性的激素刺激驱动的，这些激素刺激引起了发育中的上皮管与其相邻的胚胎间质或出生后间质之间的局部旁分泌相互作用。这种局部细胞的相互作用，反过来，协调组织重塑，最终产生成熟的导管树。虽然确切的机制尚不清楚，但我们对乳腺和其他部位分支的理解正在迅速提高。此外，在癌症的发展和进展过程中，许多这些机制被劫持、绕过或破坏。因此，更清楚地了解调节乳腺分支的潜在内分泌和旁分泌途径，可能会揭示它们是如何导致癌症的，以及如何克服或完全避免它们的不良影响。
Part of how the mammary gland fulfills its function of producing and delivering adequate amounts of milk is by forming an extensive tree-like network of branched ducts from a rudimentary epithelial bud. This process, termed branching morphogenesis, begins in fetal development, pauses after birth, resumes in response to estrogens at puberty, and is refined in response to cyclic ovarian stimulation once the margins of the mammary fat pad are met. Thus it is driven by systemic hormonal stimuli that elicit local paracrine interactions between the developing epithelial ducts and their adjacent embryonic mesenchyme or postnatal stroma. This local cellular cross-talk, in turn, orchestrates the tissue remodeling that ultimately produces a mature ductal tree. Although the precise mechanisms are still unclear, our understanding of branching in the mammary gland and elsewhere is rapidly improving. Moreover, many of these mechanisms are hijacked, bypassed, or corrupted during the development and progression of cancer. Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided.
登录
查看更多内容
影响因子：
8
作者：
Andrechek, ER;White, D;Muller, WJ
通讯作者：
Muller, WJ
影响因子：
4.8
作者：
Bocchinfuso, WP;Lindzey, JK;Korach, KS
通讯作者：
Korach, KS
影响因子：
2.5
作者：
Howard, BA;Gusterson, BA
通讯作者：
Gusterson, BA
影响因子：
6
作者：
Chen, JC;Diacovo, TG;Zutter, MM
通讯作者：
Zutter, MM
影响因子：
2.5
作者：
Conneely, OM;Jericevic, BM;Lydon, JP
通讯作者：
Lydon, JP