Developments in tandem ion mobility mass spectrometry.

Developments in tandem ion mobility mass spectrometry.
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DOI:
10.1042/bst20190788
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发表时间:
2020-12-18
影响因子:
3.9
通讯作者:
Thalassinos K
Thalassinos K
中科院分区:
生物学3区
文献类型:
--
作者:
Eldrid C;Thalassinos K

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离子迁移率(IM)与质谱(MS)联用是通过m/z和分子形状的组合从少量异质混合物中分离感兴趣物质的有用工具。虽然串联MS仪器很常见,但采用串联IM的仪器则不太常见,第一台能够进行多轮IM选择的商用IM-MS仪器将于2019年发布。在这里,我们探讨串联IM仪器的历史,最近的发展,生物系统的应用和预期的未来方向。
Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which employ tandem IM are less so with the first commercial IM–MS instrument capable of multiple IM selection rounds being released in 2019. Here we explore the history of tandem IM instruments, recent developments, the applications to biological systems and expected future directions.
DOI: 10.1007/s13361-011-0087-y
发表时间: 2011-05
影响因子: 3.2
作者:
Valentine, Stephen J.;Kurulugama, Ruwan T.;Clemmer, David E.
通讯作者: Clemmer, David E.