Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum
Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum
复制标题
鹅膏蕈酸损伤大鼠纹状体中移植纹状体神经元的功能性神经元替代
作者：
O. Isacson;P. Brundin;P. Kelly;P. T. Kelly;F. Gage;A. Björklund
在大鼠中，由所谓的兴奋性毒性氨基酸、红藻氨酸或鹅膏蕈氨酸（IA）造成的纹状体神经元破坏在基底神经节中产生神经病理学和神经化学变化1 -4，这类似于在亨廷顿舞蹈病患者中观察到的变化5，6。这种损伤的动物表现出一种行为综合征，使人联想到该疾病的主要症状7 -12，伴随着锥体外系运动系统内几个纹状体靶结构中局部脑代谢活动的大幅增加13 -15。本研究旨在探讨移植胎儿纹状体神经元植入IA损伤的纹状体，以弥补IA损伤大鼠的结构，神经化学，代谢和行为缺陷的潜力。扩展以前的研究16，17，我们在这里报告说，这种纹状体植入物可以显着改善病变引起的运动功能亢进，并至少部分正常化锥体外系神经元系统的代谢亢进。
In rats, striatal neuronal destruction by so-called excitotoxic amino acids, kainic acid or ibotenic acid (IA) produce neuropathological and neurochemical changes in the basal ganglia1–4 which resemble those seen in patients with Huntington's chorea5,6. Such lesioned animals show a behavioural syndrome which is reminiscent of the cardinal symptoms of the disease7–12, accompanied by a substantial increase in local cerebral metabolic activity in several striatal target structures within the extrapyramidal motor system13–15. The study was designed to explore the potential of grafted fetal striatal neurones implanted into the IA-lesioned striatum to compensate for the structural, neurochemical, metabolic and behavioural defects of IA-lesioned rats. Extending previous studies16,17, we report here that such striatal implants can significantly ameliorate the lesion-induced locomotor hyperactivity and at least partly normalize the metabolic hyperactivity in the extrapyramidal neuronal system.
分离麻醉和纹状体神经元电生理学。
DOI：
10.1002/syn.890090111
发表时间：
1991
期刊：
Synapse (New York, N.Y.)
影响因子：
--
作者：
Kelland,MD;Chiodo,LA;Freeman,AS
通讯作者：
Freeman,AS