Smoking cessation and the risk of diabetes mellitus and impaired fasting glucose: three-year outcomes after a quit attempt.
Smoking cessation and the risk of diabetes mellitus and impaired fasting glucose: three-year outcomes after a quit attempt.
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DOI：
10.1371/journal.pone.0098278
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Baker TB
中科院分区：
文献类型：
--
作者：
Stein JH;Asthana A;Smith SS;Piper ME;Loh WY;Fiore MC;Baker TB
戒烟后体重增加可能会增加糖尿病和空腹血糖受损(IFG)的风险。这项研究评估了戒烟和继续吸烟与戒烟三年后发生的糖尿病和IFG之间的关系。1504名吸烟者(58%为女性)平均年龄(标准差)为44.7岁(11.1岁)，每天吸烟量为21.4支(8.9支)。在914名有第3年数据的参与者中，238名戒烟者比676名继续吸烟者体重增加、腰围增加和空腹血糖水平增加(p≤0.008)。在单因素分析中，3年禁欲与糖尿病(OR = 2.60，95%CI 1.44~4.67，p = .002；4.3%绝对过量)和空腹血糖(OR = 2.43，95%CI 1.74~3.41，p<；0.0001；15.6%绝对过量)相关。在多变量分析中，糖尿病事件与高龄(p = 0.0002)、较高的基线体重(p = 0.021)、体重增加(p = 0.023)、基线吸烟率(p = 0.008)、基线空腹血糖(p<；0.0001)和基线血红蛋白A1c(均p<；0.0001)独立相关。在最终戒烟者中，吸烟更多预示着糖尿病的发生(p<；0.0001)；在持续吸烟者中，体重更重预测发生糖尿病(p = 0.0004)。戒烟与糖尿病和IFG风险增加有关。独立的危险因素包括高龄、基线体重、基线血糖状态和戒烟前较重的吸烟。这些发现可能有助于针对吸烟者进行干预，以预防血糖紊乱。ClinicalTrials.gov NCT00332644
Weight gain after smoking cessation may increase diabetes mellitus and impaired fasting glucose (IFG) risk. This study evaluated associations between smoking cessation and continued smoking with incident diabetes and IFG three years after a quit attempt. The 1504 smokers (58% female) were mean (standard deviation) 44.7 (11.1) years old and smoked 21.4 (8.9) cigarettes/day. Of 914 participants with year 3 data, the 238 abstainers had greater weight gain, increase in waist circumference, and increase in fasting glucose levels than the 676 continuing smokers (p≤0.008). In univariate analyses, Year 3 abstinence was associated with incident diabetes (OR = 2.60, 95% CI 1.44–4.67, p = .002; 4.3% absolute excess) and IFG (OR = 2.43, 95% CI 1.74–3.41, p<0.0001; 15.6% absolute excess). In multivariate analyses, incident diabetes was associated independently with older age (p = 0.0002), higher baseline body weight (p = 0.021), weight gain (p = 0.023), baseline smoking rate (p = 0.008), baseline IFG (p<0.0001), and baseline hemoglobin A1C (all p<0.0001). Smoking more at baseline predicted incident diabetes among eventual abstainers (p<0.0001); weighing more at baseline predicted incident diabetes among continuing smokers (p = 0.0004). Quitting smoking is associated with increased diabetes and IFG risk. Independent risk factors include older age, baseline body weight, baseline glycemic status, and heavier pre-quit smoking. These findings may help target smokers for interventions to prevent dysglycemia. Clinicaltrials.gov NCT00332644
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通讯作者：
Sarkin, A. J.
影响因子：
3.5
作者：
Östgren, CJ;Lindblad, U;Råstam, L
通讯作者：
Råstam, L