Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients.
Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients.
复制标题
DOI：
10.1016/j.ijrobp.2008.12.016
复制
发表时间：
2009-04-01
影响因子：
7
通讯作者：
Viswanathan, Akila N.
中科院分区：
文献类型：
--
作者：
Wo, Jennifer Y.;Viswanathan, Akila N.
Radiation has many potential long-term effects on cancer survivors. Female cancer patients may suffer from decreased fertility depending on the site irradiated. Oncologists should be aware of these consequences and discuss options for fertility preservation prior to initiating therapy. A comprehensive review of the existing literature was conducted. Studies reporting the outcomes for female patients treated with cranio-spinal, abdominal, or pelvic radiation reporting fertility, pregnancy, or neonatal-related outcomes were reviewed. Cranio-spinal irradiation elicited significant hormonal changes in women that affected their ability to become pregnant later in life. Women treated with abdomino-pelvic radiation have an increased rate of uterine dysfunction leading to miscarriage, preterm labor, low birthweight, and placental abnormalities. Early menopause results from low-dose ovarian radiation. Ovarian transposition may decrease the rates of ovarian dysfunction. There is a dose-dependent relationship between ovarian radiation therapy (RT) and premature menopause. Patients treated with RT must be aware of the impact of treatment on fertility and explore appropriate options.
登录
查看更多内容
DOI：
10.1111/j.1471-0528.1999.tb08180.x
发表时间：
1999-12-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
Bath, LE;Critchley, HOD;Wallace, WHB
通讯作者：
Wallace, WHB
DOI：
10.1111/j.1600-0412.2004.00332.x
发表时间：
2004-01-01
影响因子：
4.3
作者：
Larsen, EC;Schmiegelow, K;Andersen, AN
通讯作者：
Andersen, AN
DOI：
10.1002/mpo.2950160403
发表时间：
1988-01-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
BYRNE, J;MULVIHILL, JJ;MYERS, MH
通讯作者：
MYERS, MH
影响因子：
4.7
作者：
Howell, Simon J;Shalet, Stephen M
通讯作者：
Shalet, Stephen M
影响因子：
5.8
作者：
Chemaitilly, W;Mertens, AC;Sklar, CA
通讯作者：
Sklar, CA