Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.
Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.
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DOI：
10.1176/appi.neuropsych.11080188
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Mori S
中科院分区：
文献类型：
--
作者：
Rao V;Mielke M;Xu X;Smith GS;McCann UD;Bergey A;Doshi V;Pham DL;Yousem D;Mori S
There are currently no known early neuroanatomical markers predictive of the development of major depression or depressive symptoms after mild traumatic brain injury (mTBI). The authors conducted a 1-year longitudinal pilot study to determine whether diffusion tensor imaging (DTI) measures collected within 1 month of mTBI could predict incident depression. Of the 14 subjects who met study inclusion criteria, 4 (28.6%) developed major depression over the follow-up period. Compared with the nondepressed group, those who developed depression had white-matter abnormalities in the fronto-temporal regions measured by DTI. These preliminary results highlight the need for additional studies, including studies using a larger sample and appropriate controls.
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