Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions.
Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions.
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DOI：
10.1597/09-131
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Ghadiali SN
中科院分区：
文献类型：
--
作者：
Sheer FJ;Swarts JD;Ghadiali SN
腭裂患儿分泌性中耳炎的患病率接近100%，其发病机制被认为是咽鼓管功能障碍所致。量化婴儿CP标本中ET解剖结构的功能后果，并确定各种组织生物力学特性对CP婴儿ET功能的相对重要性。通过图像分析和三维（3D）重建技术，开发了ET解剖学和生理学的有限元模型。模型开发使用从五个婴儿CP标本获得的ET结构的组织学图像。模型参数化，不同的模型参数，其中包括张腭帆和腭帆提肌力，ET软骨，腔外粘膜的顺应性，和钩的位置对气流通过输卵管腔的阻力的影响，进行了测定。在评估的参数中，仅施加的腭帆张肌力和腔周粘膜和软骨组织的顺应性是肌肉辅助开放期间通过ET的气流阻力的显著预测因素。CP婴儿ET功能的有限元模型确定腭帆张肌力作为直接预测因子，粘膜/软骨顺应性作为肌肉辅助管腔扩张期间ET开放的间接预测因子。在CP婴儿中，没有发现钩位置和腭帆提肌力对ET功能有影响。
The prevalence of otitis media with effusion approaches 100% in infants with cleft palate (CP), and disease pathogenesis is believed to be caused by eustachian tube (ET) dysfunction. Quantify the functional consequences of ET anatomy in infant CP specimens, and identify the relative importance of various tissue biomechanical properties on ET function in infants with CP. Finite element models of ET anatomy and physiology were developed by using image analysis and three-dimensional (3D) reconstruction techniques. Models were developed using histological images of ET structures obtained from five infant CP specimens. The models were parameterized, and the effects of varying model parameters, which included tensor veli palatini and levator veli palatini force, ET cartilage, periluminal mucosal compliance, and hamular position on resistance to airflow through the tubal lumen, were determined. Of the evaluated parameters, only applied tensor veli palatini muscle force and compliance of the periluminal mucosa and cartilage tissues were significant predictors of resistance to airflow through the ET during muscle-assisted opening. Finite element models of ET function in the CP infant identified tensor veli palatini muscle force as a direct predictor and mucosal/cartilage compliance as an indirect predictor of ET opening during muscle-assisted lumen dilations. Hamular position and levator veli palatini force were not found to have an effect on ET function in CP infants.
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影响因子：
3.8
作者：
Chan, RW;Titze, IR
通讯作者：
Titze, IR
影响因子：
1.4
作者：
BLUESTONE, CD;CANTEKIN, EI;PARADISE, JL
通讯作者：
PARADISE, JL
影响因子：
3.3
作者：
Ghadiali, SN;Banks, J;Swarts, JD
通讯作者：
Swarts, JD
DOI：
10.1597/1545-1569_2000_037_0266_acoteo_2.3.co_2
发表时间：
2000-05-01
期刊：
CLEFT PALATE-CRANIOFACIAL JOURNAL
影响因子：
--
作者：
Güneren, E;Özsoy, Z;Geary, PM
通讯作者：
Geary, PM
DOI：
10.1597/04-125r.1
发表时间：
2005-09-01
期刊：
CLEFT PALATE-CRANIOFACIAL JOURNAL
影响因子：
--
作者：
Kuehn, DP;Moon, JB
通讯作者：
Moon, JB